Cerebral perfusion response to hyperoxia.
Graded levels of supplemental inspired oxygen were investigated for their viability as a noninvasive method of obtaining intravascular magnetic resonance image contrast. Administered hyperoxia has been shown to be effective as a blood oxygenation level-dependent contrast agent for magnetic resonance...
| 主要な著者: | , , , |
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
2007
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| _version_ | 1826277790402478080 |
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| author | Bulte, D Chiarelli, P Wise, R Jezzard, P |
| author_facet | Bulte, D Chiarelli, P Wise, R Jezzard, P |
| author_sort | Bulte, D |
| collection | OXFORD |
| description | Graded levels of supplemental inspired oxygen were investigated for their viability as a noninvasive method of obtaining intravascular magnetic resonance image contrast. Administered hyperoxia has been shown to be effective as a blood oxygenation level-dependent contrast agent for magnetic resonance imaging (MRI); however, it is known that high levels of inspired fraction of oxygen result in regionally decreased perfusion in the brain potentially confounding the possibility of using hyperoxia as a means of measuring blood flow and volume. Although the effects of hypoxia on blood flow have been extensively studied, the hyperoxic regime between normoxia and 100% inspired oxygen has been only intermittently studied. Subjects were studied at four levels of hyperoxia induced during a single session while perfusion was measured using arterial spin labelling MRI. Reductions in regional perfusion of grey matter were found to occur even at moderate levels of hyperoxia; however, perfusion changes at all oxygen levels were relatively mild (less than 10%) supporting the viability of hyperoxia-induced contrast. |
| first_indexed | 2024-03-06T23:34:12Z |
| format | Journal article |
| id | oxford-uuid:6d181175-49d1-4442-b35d-ddb7ee3f336a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:34:12Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:6d181175-49d1-4442-b35d-ddb7ee3f336a2022-03-26T19:15:30ZCerebral perfusion response to hyperoxia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6d181175-49d1-4442-b35d-ddb7ee3f336aEnglishSymplectic Elements at Oxford2007Bulte, DChiarelli, PWise, RJezzard, PGraded levels of supplemental inspired oxygen were investigated for their viability as a noninvasive method of obtaining intravascular magnetic resonance image contrast. Administered hyperoxia has been shown to be effective as a blood oxygenation level-dependent contrast agent for magnetic resonance imaging (MRI); however, it is known that high levels of inspired fraction of oxygen result in regionally decreased perfusion in the brain potentially confounding the possibility of using hyperoxia as a means of measuring blood flow and volume. Although the effects of hypoxia on blood flow have been extensively studied, the hyperoxic regime between normoxia and 100% inspired oxygen has been only intermittently studied. Subjects were studied at four levels of hyperoxia induced during a single session while perfusion was measured using arterial spin labelling MRI. Reductions in regional perfusion of grey matter were found to occur even at moderate levels of hyperoxia; however, perfusion changes at all oxygen levels were relatively mild (less than 10%) supporting the viability of hyperoxia-induced contrast. |
| spellingShingle | Bulte, D Chiarelli, P Wise, R Jezzard, P Cerebral perfusion response to hyperoxia. |
| title | Cerebral perfusion response to hyperoxia. |
| title_full | Cerebral perfusion response to hyperoxia. |
| title_fullStr | Cerebral perfusion response to hyperoxia. |
| title_full_unstemmed | Cerebral perfusion response to hyperoxia. |
| title_short | Cerebral perfusion response to hyperoxia. |
| title_sort | cerebral perfusion response to hyperoxia |
| work_keys_str_mv | AT bulted cerebralperfusionresponsetohyperoxia AT chiarellip cerebralperfusionresponsetohyperoxia AT wiser cerebralperfusionresponsetohyperoxia AT jezzardp cerebralperfusionresponsetohyperoxia |