Stress-activated MAP kinases in chromatin and transcriptional complexes

Stress-activated MAP kinases (SAPKs) are activated by stressors or by certain physiological stimuli and mediate an intracellular response appropriate to the change in environment. Long-term adaptation requires reprogramming of transcription and one of the most significant actions of SAPK cascades is...

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Main Authors: Crump, N, Han, Y, Mahadevan, L
Format: Journal article
Language:English
Published: 2008
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author Crump, N
Han, Y
Mahadevan, L
author_facet Crump, N
Han, Y
Mahadevan, L
author_sort Crump, N
collection OXFORD
description Stress-activated MAP kinases (SAPKs) are activated by stressors or by certain physiological stimuli and mediate an intracellular response appropriate to the change in environment. Long-term adaptation requires reprogramming of transcription and one of the most significant actions of SAPK cascades is therefore induction of gene expression. SAPKs and their downstream kinases phosphorylate many chromatin-associated and transcription factors. Further, they can induce localised histone modification by regulating histone acetyltransferases and deacetylases. p38/SAPK2 also elicits phosphorylation of the nucleosomal proteins histone H3 and HMGN1 (previously HMG-14) via the downstream mitogen- and stress-stimulated kinases MSK1/2. Finally, recent evidence indicates a novel non-enzymatic SAPK function in transcriptional complexes, suggesting a more structural role. The yeast SAPK Hog1p is recruited to a proportion of its target genes on activation and localises beyond the promoter into coding regions. The observation that Hog1p interacts with elongating RNA polymerase II in addition to several transcriptional elongation factors has led to the suggestion that this SAPK may behave like an elongation factor at some target genes. The generality of this new function is discussed. © 2007 Springer-Verlag Berlin Heidelberg.
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spelling oxford-uuid:6d21cc63-6715-459a-9f34-7beae4b304472022-03-26T19:15:47ZStress-activated MAP kinases in chromatin and transcriptional complexesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6d21cc63-6715-459a-9f34-7beae4b30447EnglishSymplectic Elements at Oxford2008Crump, NHan, YMahadevan, LStress-activated MAP kinases (SAPKs) are activated by stressors or by certain physiological stimuli and mediate an intracellular response appropriate to the change in environment. Long-term adaptation requires reprogramming of transcription and one of the most significant actions of SAPK cascades is therefore induction of gene expression. SAPKs and their downstream kinases phosphorylate many chromatin-associated and transcription factors. Further, they can induce localised histone modification by regulating histone acetyltransferases and deacetylases. p38/SAPK2 also elicits phosphorylation of the nucleosomal proteins histone H3 and HMGN1 (previously HMG-14) via the downstream mitogen- and stress-stimulated kinases MSK1/2. Finally, recent evidence indicates a novel non-enzymatic SAPK function in transcriptional complexes, suggesting a more structural role. The yeast SAPK Hog1p is recruited to a proportion of its target genes on activation and localises beyond the promoter into coding regions. The observation that Hog1p interacts with elongating RNA polymerase II in addition to several transcriptional elongation factors has led to the suggestion that this SAPK may behave like an elongation factor at some target genes. The generality of this new function is discussed. © 2007 Springer-Verlag Berlin Heidelberg.
spellingShingle Crump, N
Han, Y
Mahadevan, L
Stress-activated MAP kinases in chromatin and transcriptional complexes
title Stress-activated MAP kinases in chromatin and transcriptional complexes
title_full Stress-activated MAP kinases in chromatin and transcriptional complexes
title_fullStr Stress-activated MAP kinases in chromatin and transcriptional complexes
title_full_unstemmed Stress-activated MAP kinases in chromatin and transcriptional complexes
title_short Stress-activated MAP kinases in chromatin and transcriptional complexes
title_sort stress activated map kinases in chromatin and transcriptional complexes
work_keys_str_mv AT crumpn stressactivatedmapkinasesinchromatinandtranscriptionalcomplexes
AT hany stressactivatedmapkinasesinchromatinandtranscriptionalcomplexes
AT mahadevanl stressactivatedmapkinasesinchromatinandtranscriptionalcomplexes