Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV)
Novel amidinourea derivatives have been synthesised and evaluated for their antiviral activity against Hepatitis C Virus (HCV). A compound with an amidinourea-spermine chemical structure, different from that of standard anti-HCV drugs, showed micromolar activity against HCV and excellent viability....
| Autores principales: | , , , , |
|---|---|
| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
|
| _version_ | 1826277808304816128 |
|---|---|
| author | Magri, A Mokrane, O Lauder, K Patel, A Castagnolo, D |
| author_facet | Magri, A Mokrane, O Lauder, K Patel, A Castagnolo, D |
| author_sort | Magri, A |
| collection | OXFORD |
| description | Novel amidinourea derivatives have been synthesised and evaluated for their antiviral activity against Hepatitis C Virus (HCV). A compound with an amidinourea-spermine chemical structure, different from that of standard anti-HCV drugs, showed micromolar activity against HCV and excellent viability. Studies on the mode of action revealed that the new compound may act against HCV through the inhibition of IRES-mediated translation. |
| first_indexed | 2024-03-06T23:34:29Z |
| format | Journal article |
| id | oxford-uuid:6d2bf33c-a2fb-4f76-a5bd-00a96ee55d47 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:34:29Z |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:6d2bf33c-a2fb-4f76-a5bd-00a96ee55d472022-03-26T19:16:13ZSynthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV)Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6d2bf33c-a2fb-4f76-a5bd-00a96ee55d47EnglishSymplectic Elements at OxfordElsevier2019Magri, AMokrane, OLauder, KPatel, ACastagnolo, DNovel amidinourea derivatives have been synthesised and evaluated for their antiviral activity against Hepatitis C Virus (HCV). A compound with an amidinourea-spermine chemical structure, different from that of standard anti-HCV drugs, showed micromolar activity against HCV and excellent viability. Studies on the mode of action revealed that the new compound may act against HCV through the inhibition of IRES-mediated translation. |
| spellingShingle | Magri, A Mokrane, O Lauder, K Patel, A Castagnolo, D Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV) |
| title | Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV) |
| title_full | Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV) |
| title_fullStr | Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV) |
| title_full_unstemmed | Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV) |
| title_short | Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV) |
| title_sort | synthesis biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis c virus hcv |
| work_keys_str_mv | AT magria synthesisbiologicalevaluationandmodeofactionstudiesofnovelamidinoureainhibitorsofhepatitiscvirushcv AT mokraneo synthesisbiologicalevaluationandmodeofactionstudiesofnovelamidinoureainhibitorsofhepatitiscvirushcv AT lauderk synthesisbiologicalevaluationandmodeofactionstudiesofnovelamidinoureainhibitorsofhepatitiscvirushcv AT patela synthesisbiologicalevaluationandmodeofactionstudiesofnovelamidinoureainhibitorsofhepatitiscvirushcv AT castagnolod synthesisbiologicalevaluationandmodeofactionstudiesofnovelamidinoureainhibitorsofhepatitiscvirushcv |