Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV)

Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV)

Novel amidinourea derivatives have been synthesised and evaluated for their antiviral activity against Hepatitis C Virus (HCV). A compound with an amidinourea-spermine chemical structure, different from that of standard anti-HCV drugs, showed micromolar activity against HCV and excellent viability....

Полное описание

Библиографические подробности
Главные авторы:	Magri, A, Mokrane, O, Lauder, K, Patel, A, Castagnolo, D
Формат:	Journal article
Язык:	English
Опубликовано:	Elsevier 2019

Схожие документы

Synthesis and Biological Evaluation of Amidinourea Derivatives against Herpes Simplex Viruses
по: Anita Toscani, и др.
Опубликовано: (2021-08-01)

Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance
по: Auda A. Eltahla, и др.
Опубликовано: (2015-09-01)

A gram-scale synthesis of a macrocyclic amidinourea with strong antifungal activity through a Fukuyama tri-protected polyamine intermediate
по: Matteo Borgini, и др.
Опубликовано: (2019-05-01)

Synthesis of New Indanyl Nucleoside Analogues and their Biological Evaluation on Hepatitis C Virus (HCV) Replicon
по: Matías E. Gómez, и др.
Опубликовано: (2019-03-01)

Analytical and Biological Variables Influencing Quantitative Hepatitis C Virus (HCV) Measurement in HIV-HCV Coinfection
по: Curtis Cooper, и др.
Опубликовано: (2006-01-01)

Hepatitis C Virus (HCV) Infection and Hepatic Steatosis
Опубликовано: (2006-04-01)

Secondary Attack Rate of Hepatitis C Virus (HCV)
по: José A. Cisneros-Rodríguez, и др.
Опубликовано: (2024-02-01)

Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Dual Infection
Опубликовано: (2006-04-01)

GP73 is upregulated by hepatitis C virus (HCV) infection and enhances HCV secretion.
по: Longbo Hu, и др.
Опубликовано: (2014-01-01)

Relative contribution of iron genes, dysmetabolism and hepatitis C virus (HCV) in the pathogenesis of altered iron regulation in HCV chronic hepatitis
по: Luca Valenti, и др.
Опубликовано: (2007-08-01)

Hepatitis C virus (HCV) diagnosis via microfluidics
по: Narayanamurthy, Vigneswaran, и др.
Опубликовано: (2021)

CD81 and Hepatitis C Virus (HCV) Infection
по: Lucie Fénéant, и др.
Опубликовано: (2014-02-01)

The Natural History of Hepatitis C Virus (HCV) Infection
Опубликовано: (2006-04-01)

VAPC, an human endogenous inhibitor for hepatitis C virus (HCV) infection, is intrinsically unstructured but forms a "fuzzy complex" with HCV NS5B.
по: Shaveta Goyal, и др.
Опубликовано: (2012-01-01)

Alcohol Consumption and Hepatitis C Virus (HCV) RNA Levels in HIV/HCV Coinfected Patients
по: Daniel Fuster, и др.
Опубликовано: (2021-04-01)

Optimized Hepatitis C Virus (HCV) E2 Glycoproteins and their Immunogenicity in Combination with MVA-HCV
по: María Q. Marín, и др.
Опубликовано: (2020-08-01)

Hepatitis C Virus (HCV)–Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design
по: Florian Wrensch, и др.
Опубликовано: (2018-06-01)

Prevalence of mixed hepatitis C virus (HCV) genotypes among recently diagnosed dialysis patients with HCV infection
по: Mohammed A Al Balwi
Опубликовано: (2011-01-01)

Liver histology in co-infection of hepatitis C virus (HCV) and Hepatitis G virus (HGV)
по: STRAUSS Edna, и др.
Опубликовано: (2002-01-01)

Hepatitis B Virus (HBV) Reactivation Following Pharmacological Eradication of Hepatitis C Virus (HCV)
по: Mariantonietta Pisaturo, и др.
Опубликовано: (2019-09-01)

Optimizing Hepatitis C Therapy in HIV/hepatitis C Virus (HCV) Coinfected Patients: Analysis of HCV Viral Kinetics on Treatment
по: Paul Damien James, и др.
Опубликовано: (2012-01-01)

Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
по: Kasprowicz, V, и др.
Опубликовано: (2011)

Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution.
по: Kasprowicz, V, и др.
Опубликовано: (2010)

INCREASE OF LIPIDS DURING HCV TREATMENT: VIRUS ACTION OR MEDICATION?
по: Vanessa Gutierrez de ANDRADE, и др.

Hepatitis C virus (HCV) micro-elimination in the hospital setting: The results of the HCV Caserta hospital project
по: Vincenzo Messina, и др.
Опубликовано: (2022-05-01)

Significance of hepatitis C virus (HCV) viremia in anti-HCV antibody (IgG) positive subjects
по: Sukrutha Gopal, и др.
Опубликовано: (2017-01-01)

School adolescents’ knowledge concerning hepatitis C virus (HCV)
по: Lidia Sierpińska, и др.
Опубликовано: (2017-01-01)

Hepatitis C Virus (HCV) Prediction by Machine Learning Techniques
по: Satish CR Nandipati, и др.
Опубликовано: (2020-03-01)

Molecular Virology of Hepatitis C Virus (HCV): 2006 Update
Опубликовано: (2006-04-01)

Hepatitis C Virus Infection and HCV Genotypes of Hemodialysis Patients
по: K Samimi-rad, и др.
Опубликовано: (2008-09-01)

Hepatitis C Virus Infection and HCV Genotypes of Hemodialysis Patients
по: K Samimi-rad, и др.
Опубликовано: (2008-09-01)

School adolescents’ knowledge concerning hepatitis C virus (HCV)
по: Lidia Sierpińska, и др.
Опубликовано: (2017-01-01)

School adolescents’ knowledge concerning hepatitis C virus (HCV)
по: Lidia Sierpińska, и др.
Опубликовано: (2017-06-01)

HCV Seroreactivity and Detection of HCV RNA in Hepatitis Cases
по: Mahantesh B Nagamoti, и др.
Опубликовано: (2018-04-01)

Experimental models for hepatitis C virus (HCV): New opportunities for combating hepatitis C
по: Karina del Carmen Trujillo-Murillo, Ph.D., и др.
Опубликовано: (2004-04-01)

New pandemics: HIV and AIDS, HCV and chronic hepatitis, Influenza virus and flu
по: Cohen Éric A, и др.
Опубликовано: (2007-02-01)

Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection.
по: Hung-Yin Liu, и др.
Опубликовано: (2021-01-01)

Analysis of hepatitis C virus (HCV) RNA load in platelets of HCV-monoinfected patients receiving antiviral therapy
по: Márcia Paschoal do Espírito-Santo, и др.
Опубликовано: (2013-05-01)

Investigation of Hepatitis C (HCV) Virus Epidemiology in the Capital City of Türkiye
по: Fatih Mehmet Akıllı
Опубликовано: (2024-12-01)

Management of hepatitis C virus (HCV) infection in drug substitution programs
по: K Hensel-Koch, и др.
Опубликовано: (2011-05-01)