Model membrane systems to reconstitute immune cell signaling
Understanding the broad variety of functions encoded in cellular membranes requires experimental systems mimicking both their biochemical composition and biophysical properties. Here, we review the interplay between membrane components and the physical properties of the plasma membrane worth conside...
| Autors principals: | , , , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
Wiley
2020
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| _version_ | 1826277861451890688 |
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| author | Céspedes, PF Beckers, D Dustin, ML Sezgin, E |
| author_facet | Céspedes, PF Beckers, D Dustin, ML Sezgin, E |
| author_sort | Céspedes, PF |
| collection | OXFORD |
| description | Understanding the broad variety of functions encoded in cellular membranes requires experimental systems mimicking both their biochemical composition and biophysical properties. Here, we review the interplay between membrane components and the physical properties of the plasma membrane worth considering for biomimetic studies. Later, we discuss the main advantages and caveats of different model membrane systems. We further expand on how the use of model systems has contributed to the understanding of immune cell signaling, with a specific focus on the immunological synapse. We discuss the similarities of immune synapses observed for innate and adaptive immune cells and focus on the physical principles underlying these similarities. |
| first_indexed | 2024-03-06T23:35:16Z |
| format | Journal article |
| id | oxford-uuid:6d719ded-f3a7-43d6-a87c-961f4aaed1b3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:35:16Z |
| publishDate | 2020 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:6d719ded-f3a7-43d6-a87c-961f4aaed1b32022-03-26T19:17:48ZModel membrane systems to reconstitute immune cell signalingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6d719ded-f3a7-43d6-a87c-961f4aaed1b3EnglishSymplectic ElementsWiley2020Céspedes, PFBeckers, DDustin, MLSezgin, EUnderstanding the broad variety of functions encoded in cellular membranes requires experimental systems mimicking both their biochemical composition and biophysical properties. Here, we review the interplay between membrane components and the physical properties of the plasma membrane worth considering for biomimetic studies. Later, we discuss the main advantages and caveats of different model membrane systems. We further expand on how the use of model systems has contributed to the understanding of immune cell signaling, with a specific focus on the immunological synapse. We discuss the similarities of immune synapses observed for innate and adaptive immune cells and focus on the physical principles underlying these similarities. |
| spellingShingle | Céspedes, PF Beckers, D Dustin, ML Sezgin, E Model membrane systems to reconstitute immune cell signaling |
| title | Model membrane systems to reconstitute immune cell signaling |
| title_full | Model membrane systems to reconstitute immune cell signaling |
| title_fullStr | Model membrane systems to reconstitute immune cell signaling |
| title_full_unstemmed | Model membrane systems to reconstitute immune cell signaling |
| title_short | Model membrane systems to reconstitute immune cell signaling |
| title_sort | model membrane systems to reconstitute immune cell signaling |
| work_keys_str_mv | AT cespedespf modelmembranesystemstoreconstituteimmunecellsignaling AT beckersd modelmembranesystemstoreconstituteimmunecellsignaling AT dustinml modelmembranesystemstoreconstituteimmunecellsignaling AT sezgine modelmembranesystemstoreconstituteimmunecellsignaling |