RNAs: regulators of bacterial virulence.
RNA-based pathways that regulate protein expression are much more widespread than previously thought. Regulatory RNAs, including 5' and 3' untranslated regions next to the coding sequence, cis-acting antisense RNAs and trans-acting small non-coding RNAs, are effective regulatory molecules...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797074393072926720 |
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| author | Gripenland, J Netterling, S Loh, E Tiensuu, T Toledo-Arana, A Johansson, J |
| author_facet | Gripenland, J Netterling, S Loh, E Tiensuu, T Toledo-Arana, A Johansson, J |
| author_sort | Gripenland, J |
| collection | OXFORD |
| description | RNA-based pathways that regulate protein expression are much more widespread than previously thought. Regulatory RNAs, including 5' and 3' untranslated regions next to the coding sequence, cis-acting antisense RNAs and trans-acting small non-coding RNAs, are effective regulatory molecules that can influence protein expression and function in response to external cues such as temperature, pH and levels of metabolites. This Review discusses the mechanisms by which these regulatory RNAs, together with accessory proteins such as RNases, control the fate of mRNAs and proteins and how this regulation influences virulence in pathogenic bacteria. |
| first_indexed | 2024-03-06T23:35:29Z |
| format | Journal article |
| id | oxford-uuid:6d8354db-32e1-41a6-94ab-60a49e439118 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:35:29Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:6d8354db-32e1-41a6-94ab-60a49e4391182022-03-26T19:18:13ZRNAs: regulators of bacterial virulence.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6d8354db-32e1-41a6-94ab-60a49e439118EnglishSymplectic Elements at Oxford2010Gripenland, JNetterling, SLoh, ETiensuu, TToledo-Arana, AJohansson, JRNA-based pathways that regulate protein expression are much more widespread than previously thought. Regulatory RNAs, including 5' and 3' untranslated regions next to the coding sequence, cis-acting antisense RNAs and trans-acting small non-coding RNAs, are effective regulatory molecules that can influence protein expression and function in response to external cues such as temperature, pH and levels of metabolites. This Review discusses the mechanisms by which these regulatory RNAs, together with accessory proteins such as RNases, control the fate of mRNAs and proteins and how this regulation influences virulence in pathogenic bacteria. |
| spellingShingle | Gripenland, J Netterling, S Loh, E Tiensuu, T Toledo-Arana, A Johansson, J RNAs: regulators of bacterial virulence. |
| title | RNAs: regulators of bacterial virulence. |
| title_full | RNAs: regulators of bacterial virulence. |
| title_fullStr | RNAs: regulators of bacterial virulence. |
| title_full_unstemmed | RNAs: regulators of bacterial virulence. |
| title_short | RNAs: regulators of bacterial virulence. |
| title_sort | rnas regulators of bacterial virulence |
| work_keys_str_mv | AT gripenlandj rnasregulatorsofbacterialvirulence AT netterlings rnasregulatorsofbacterialvirulence AT lohe rnasregulatorsofbacterialvirulence AT tiensuut rnasregulatorsofbacterialvirulence AT toledoaranaa rnasregulatorsofbacterialvirulence AT johanssonj rnasregulatorsofbacterialvirulence |