Neural circuitry coordinating male copulation
Copulation is the goal of the courtship process, crucial to reproductive success and evolutionary fitness. Identifying the circuitry underlying copulation is a necessary step towards understanding universal principles of circuit operation, and how circuit elements are recruited into the production o...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Published: |
eLife Sciences Publication
2016
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| _version_ | 1826277879196942336 |
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| author | Goodwin, S Pavlou, H Neville, M Nojima, T Lin, A Diao, F Chen, B White, B |
| author_facet | Goodwin, S Pavlou, H Neville, M Nojima, T Lin, A Diao, F Chen, B White, B |
| author_sort | Goodwin, S |
| collection | OXFORD |
| description | Copulation is the goal of the courtship process, crucial to reproductive success and evolutionary fitness. Identifying the circuitry underlying copulation is a necessary step towards understanding universal principles of circuit operation, and how circuit elements are recruited into the production of ordered action sequences. Here, we identify key sex-specific neurons that mediate copulation in Drosophila, and define a sexually dimorphic motor circuit in the male abdominal ganglion that mediates the action sequence of initiating and terminating copulation. This sexually dimorphic circuit composed of three neuronal classes – motor neurons, interneurons and mechanosensory neurons – controls the mechanics of copulation. By correlating the connectivity, function and activity of these neurons we have determined the logic for how this circuitry is coordinated to generate this male-specific behavior, and sets the stage for a circuit-level dissection of active sensing and modulation of copulatory behavior. |
| first_indexed | 2024-03-06T23:35:33Z |
| format | Journal article |
| id | oxford-uuid:6d879888-c52f-42ff-bb39-275d74bf3483 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:35:33Z |
| publishDate | 2016 |
| publisher | eLife Sciences Publication |
| record_format | dspace |
| spelling | oxford-uuid:6d879888-c52f-42ff-bb39-275d74bf34832022-03-26T19:18:23ZNeural circuitry coordinating male copulationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6d879888-c52f-42ff-bb39-275d74bf3483Symplectic Elements at OxfordeLife Sciences Publication2016Goodwin, SPavlou, HNeville, MNojima, TLin, ADiao, FChen, BWhite, BCopulation is the goal of the courtship process, crucial to reproductive success and evolutionary fitness. Identifying the circuitry underlying copulation is a necessary step towards understanding universal principles of circuit operation, and how circuit elements are recruited into the production of ordered action sequences. Here, we identify key sex-specific neurons that mediate copulation in Drosophila, and define a sexually dimorphic motor circuit in the male abdominal ganglion that mediates the action sequence of initiating and terminating copulation. This sexually dimorphic circuit composed of three neuronal classes – motor neurons, interneurons and mechanosensory neurons – controls the mechanics of copulation. By correlating the connectivity, function and activity of these neurons we have determined the logic for how this circuitry is coordinated to generate this male-specific behavior, and sets the stage for a circuit-level dissection of active sensing and modulation of copulatory behavior. |
| spellingShingle | Goodwin, S Pavlou, H Neville, M Nojima, T Lin, A Diao, F Chen, B White, B Neural circuitry coordinating male copulation |
| title | Neural circuitry coordinating male copulation |
| title_full | Neural circuitry coordinating male copulation |
| title_fullStr | Neural circuitry coordinating male copulation |
| title_full_unstemmed | Neural circuitry coordinating male copulation |
| title_short | Neural circuitry coordinating male copulation |
| title_sort | neural circuitry coordinating male copulation |
| work_keys_str_mv | AT goodwins neuralcircuitrycoordinatingmalecopulation AT pavlouh neuralcircuitrycoordinatingmalecopulation AT nevillem neuralcircuitrycoordinatingmalecopulation AT nojimat neuralcircuitrycoordinatingmalecopulation AT lina neuralcircuitrycoordinatingmalecopulation AT diaof neuralcircuitrycoordinatingmalecopulation AT chenb neuralcircuitrycoordinatingmalecopulation AT whiteb neuralcircuitrycoordinatingmalecopulation |