Inhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders.
A review is given on some of the more recent knowledge of the enzymes involved in the control of glycosphingolipids biosynthesis and how catabolic deficiency leads to the glycosphingolipidoses. Focus is on how small-molecule inhibitors have been instrumental in probing the enzymes in these pathways...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
ACS
2000
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| _version_ | 1797074398522376192 |
|---|---|
| author | Butters, T Dwek, R Platt, F |
| author_facet | Butters, T Dwek, R Platt, F |
| author_sort | Butters, T |
| collection | OXFORD |
| description | A review is given on some of the more recent knowledge of the enzymes involved in the control of glycosphingolipids biosynthesis and how catabolic deficiency leads to the glycosphingolipidoses. Focus is on how small-molecule inhibitors have been instrumental in probing the enzymes in these pathways and how their application has been taken from discovery in the laboratory to therapeutic use in man. |
| first_indexed | 2024-03-06T23:35:34Z |
| format | Journal article |
| id | oxford-uuid:6d896866-4a0c-4fc5-855c-d5d9d140e392 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:35:34Z |
| publishDate | 2000 |
| publisher | ACS |
| record_format | dspace |
| spelling | oxford-uuid:6d896866-4a0c-4fc5-855c-d5d9d140e3922022-03-26T19:18:22ZInhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6d896866-4a0c-4fc5-855c-d5d9d140e392EnglishSymplectic Elements at OxfordACS2000Butters, TDwek, RPlatt, FA review is given on some of the more recent knowledge of the enzymes involved in the control of glycosphingolipids biosynthesis and how catabolic deficiency leads to the glycosphingolipidoses. Focus is on how small-molecule inhibitors have been instrumental in probing the enzymes in these pathways and how their application has been taken from discovery in the laboratory to therapeutic use in man. |
| spellingShingle | Butters, T Dwek, R Platt, F Inhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders. |
| title | Inhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders. |
| title_full | Inhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders. |
| title_fullStr | Inhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders. |
| title_full_unstemmed | Inhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders. |
| title_short | Inhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders. |
| title_sort | inhibition of glycosphingolipid biosynthesis application to lysosomal storage disorders |
| work_keys_str_mv | AT butterst inhibitionofglycosphingolipidbiosynthesisapplicationtolysosomalstoragedisorders AT dwekr inhibitionofglycosphingolipidbiosynthesisapplicationtolysosomalstoragedisorders AT plattf inhibitionofglycosphingolipidbiosynthesisapplicationtolysosomalstoragedisorders |