Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties.

Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties.

Shaker-like (KV1.1) channels contain a highly conserved Pro-Val-Pro (PVP) motif at the base of S6 that produces a kink in the S6 helices and provides a flexible element thought to be essential for channel gating. The role of proline-induced kinks in transmembrane helices is well known, but the contr...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Imbrici, P, Grottesi, A, D'Adamo, M, Mannucci, R, Tucker, S, Pessia, M
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2009

Những quyển sách tương tự

Role of receptor protein tyrosine phosphatase alpha (RPTPalpha) and tyrosine phosphorylation in the serotonergic inhibition of voltage-dependent potassium channels.
Bằng: Imbrici, P, et al.
Được phát hành: (2000)

Modulation of hKv1.1 and hKv1.2 voltage gating and C-type inactivation by 5-HT2C receptors
Bằng: Imbrici, P, et al.
Được phát hành: (2000)

Commentary: A channelopathy mutation in the voltage-sensor discloses contributions of a conserved phenylalanine to gating properties of Kv1.1 channels and ataxia
Bằng: Sonia Hasan, et al.
Được phát hành: (2018-06-01)

pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia.
Bằng: Tucker, S, et al.
Được phát hành: (2000)

Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1.
Bằng: Pessia, M, et al.
Được phát hành: (2001)

The intrinsic flexibility of the Kv voltage sensor and its implications for channel gating.
Bằng: Sands, Z, et al.
Được phát hành: (2006)

Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels.
Bằng: Casamassima, M, et al.
Được phát hành: (2003)

Voltage-gated ion channels.
Bằng: Sands, Z, et al.
Được phát hành: (2005)

Altered functional properties of a missense variant in the TRESK K+ channel (KCNK18) associated with migraine and intellectual disability
Bằng: Imbrici, P, et al.
Được phát hành: (2020)

Hydrophobic gating in ion channels.
Bằng: Aryal, P, et al.
Được phát hành: (2015)

Differential pH sensitivity of Kir4.1 and Kir4.2 and their modulation by heteropolymerisation with Kir5.1
Bằng: Pessia, M, et al.
Được phát hành: (2001)

Genetic Inactivation of Kcnj16 Identifies Kir5.1 as an Important Determinant of Neuronal PCO2/pH Sensitivity
Bằng: D'Adamo, M, et al.
Được phát hành: (2011)

A channelopathy mutation in the voltage-sensor discloses contributions of a conserved phenylalanine to gating properties of Kv1.1 channels and ataxia
Bằng: Sonia Hasan, et al.
Được phát hành: (2017-07-01)

Exact solution of the Floquet-PXP cellular automaton
Bằng: Wilkinson, JWP, et al.
Được phát hành: (2020)

When is a hydrophobic gate not a hydrophobic gate?
Bằng: Seiferth, D, et al.
Được phát hành: (2022)

Water and hydrophobic gates in ion channels and nanopores
Bằng: Rao, S, et al.
Được phát hành: (2018)

Autism with Seizures and Intellectual Disability: Possible Causative Role of Gain-of-function of the Inwardly-Rectifying K+ Channel Kir4.1
Bằng: Federico Sicca, et al.
Được phát hành: (2011-07-01)

Hydrophobic gating in BK channels
Bằng: Zhiguang Jia, et al.
Được phát hành: (2018-08-01)

Constraint-induced breaking and restoration of ergodicity in spin-1 PXP models
Bằng: Bhaskar Mukherjee, et al.
Được phát hành: (2021-08-01)

Molecular simulations of hydrophobic gating of pentameric ligand gated ion channels: Insights into water and ions
Bằng: Rao, S, et al.
Được phát hành: (2021)

The importance of surface character, geometry and flexibility in a hydrophobic gating mechanism for ion channels
Bằng: Beckstein, O, et al.
Được phát hành: (2004)

Muscarine-gated K+ channel: subunit stoichiometry and structural domains essential for G protein stimulation.
Bằng: Tucker, S, et al.
Được phát hành: (1996)

The muscarinic-gated K+ channel: Subunit stoichiometry and structural domains essential for G protein stimulation
Bằng: Tucker, S, et al.
Được phát hành: (1996)

A novel KCNA1 mutation identified in an Italian family affected by episodic ataxia type 1.
Bằng: Imbrici, P, et al.
Được phát hành: (2008)

New working equipment of PXP 2.0 high-performance railway train
Bằng: Ilinykh Andrey, et al.
Được phát hành: (2024-01-01)

Being flexible: the voltage-controllable activation gate of Kv channels
Bằng: Alain J. Labro, et al.
Được phát hành: (2012-09-01)

Kcnj16 (Kir5.1) gene ablation causes subfertility and increases the prevalence of morphologically abnormal spermatozoa
Bằng: Poli, G, et al.
Được phát hành: (2021)

Hydrophobic gating and functional annotation of ion channels
Bằng: Klesse, G
Được phát hành: (2019)

Publisher Correction: Hydrophobic gating in BK channels
Bằng: Zhiguang Jia, et al.
Được phát hành: (2020-09-01)

Identification of mutations in Kir5.1 which affect time-dependent activation of heteromeric Kir4.1/Kir5.1 potassium channels
Bằng: Tucker, S, et al.
Được phát hành: (2002)

Conformational dynamics of M2 helices in KirBac channels: helix flexibility in relation to gating via molecular dynamics simulations.
Bằng: Grottesi, A, et al.
Được phát hành: (2005)

Ion channel gates: comparative analysis of energy barriers.
Bằng: Tai, K, et al.
Được phát hành: (2009)

Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise.
Bằng: Cian eO‘Donnell, et al.
Được phát hành: (2014-09-01)

Voltage gating of a biomimetic nanopore: Electrowetting of a hydrophobic barrier
Bằng: Sansom, M, et al.
Được phát hành: (2017)

Co-creating and hosting PxP: a conference about patient engagement in research for and by patient partners
Bằng: Dawn P. Richards, et al.
Được phát hành: (2024-07-01)

Hydrophobic Gating of Ion Permeation in Magnesium Channel CorA.
Bằng: Chris Neale, et al.
Được phát hành: (2015-07-01)

Water, Protons, and the Gating of Voltage-Gated Potassium Channels
Bằng: Alisher M. Kariev, et al.
Được phát hành: (2024-01-01)

Voltage-gated sodium channels assemble and gate as dimers
Bằng: Jérôme Clatot, et al.
Được phát hành: (2017-12-01)

Multiple mechanisms contribute to fluorometry signals from the voltage-gated proton channel
Bằng: Ferenc Papp, et al.
Được phát hành: (2022-10-01)

A heuristic derived from analysis of the ion channel structural proteome permits the rapid identification of hydrophobic gates
Bằng: Rao, S, et al.
Được phát hành: (2019)