The KCNJ11-E23K gene variant hastens diabetes progression by impairing glucose-induced insulin secretion

The KCNJ11-E23K gene variant hastens diabetes progression by impairing glucose-induced insulin secretion

The ATP-sensitive K+ (KATP) channel controls blood glucose levels by coupling glucose metabolism to insulin secretion in pancreatic β-cells. E23K, a common polymorphism in the pore-forming KATP channel subunit (KCNJ11) gene, has been linked to increased risk of type 2 diabetes. Understanding the ris...

Podrobná bibliografie
Hlavní autoři:	Sachse, G, Haythorne, E, Hill, T, Proks, P, Joynson, R, Terrón-Expósito, R, Bentley, L, Tucker, SJ, Cox, RD, Ashcroft, FM
Médium:	Journal article
Jazyk:	English
Vydáno:	American Diabetes Association 2021

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