Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues
Enantioenriched tetrafluorinated aryl-C-nucleosides were synthesised in four steps from 1-benzyloxy-4-bromo-3,3,4,4-tetrafluorobutan-2-ol. The presence of the tetrafluorinated ethylene group is compatible with O-phosphorylation of the primary alcohol, as demonstrated by the successful preparation of...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797074462433083392 |
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| author | Bonnac, L Lee, SE Giuffredi, G Elphick, L Anderson, A Child, E Mann, D Gouverneur, V |
| author_facet | Bonnac, L Lee, SE Giuffredi, G Elphick, L Anderson, A Child, E Mann, D Gouverneur, V |
| author_sort | Bonnac, L |
| collection | OXFORD |
| description | Enantioenriched tetrafluorinated aryl-C-nucleosides were synthesised in four steps from 1-benzyloxy-4-bromo-3,3,4,4-tetrafluorobutan-2-ol. The presence of the tetrafluorinated ethylene group is compatible with O-phosphorylation of the primary alcohol, as demonstrated by the successful preparation of the tetrafluorinated naphthyl-C-nucleotide. © 2010 The Royal Society of Chemistry. |
| first_indexed | 2024-03-06T23:36:31Z |
| format | Journal article |
| id | oxford-uuid:6ddb43cb-ddca-41f0-984e-89f340caa678 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:36:31Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:6ddb43cb-ddca-41f0-984e-89f340caa6782022-03-26T19:20:28ZSynthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analoguesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6ddb43cb-ddca-41f0-984e-89f340caa678EnglishSymplectic Elements at Oxford2010Bonnac, LLee, SEGiuffredi, GElphick, LAnderson, AChild, EMann, DGouverneur, VEnantioenriched tetrafluorinated aryl-C-nucleosides were synthesised in four steps from 1-benzyloxy-4-bromo-3,3,4,4-tetrafluorobutan-2-ol. The presence of the tetrafluorinated ethylene group is compatible with O-phosphorylation of the primary alcohol, as demonstrated by the successful preparation of the tetrafluorinated naphthyl-C-nucleotide. © 2010 The Royal Society of Chemistry. |
| spellingShingle | Bonnac, L Lee, SE Giuffredi, G Elphick, L Anderson, A Child, E Mann, D Gouverneur, V Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues |
| title | Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues |
| title_full | Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues |
| title_fullStr | Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues |
| title_full_unstemmed | Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues |
| title_short | Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues |
| title_sort | synthesis and o phosphorylation of 3 3 4 4 tetrafluoroaryl c nucleoside analogues |
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