Factors associated with ventilatory failure in obesity
<p>INTRODUCTION: Only a third of obese patients develop chronic ventilatory failure. This cross-sectional study assessed multiple factors potentially associated with chronic ventilatory failure.</p> <p>MATERIALS/PATIENTS AND METHODS:</p> <p>Participants had a body mas...
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| Other Authors: | |
| Format: | Thesis |
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2016
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| _version_ | 1797074496358711296 |
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| author | Manuel, A |
| author2 | Stradling, J |
| author_facet | Stradling, J Manuel, A |
| author_sort | Manuel, A |
| collection | OXFORD |
| description | <p>INTRODUCTION: Only a third of obese patients develop chronic ventilatory failure. This cross-sectional study assessed multiple factors potentially associated with chronic ventilatory failure.</p> <p>MATERIALS/PATIENTS AND METHODS:</p> <p>Participants had a body mass index (BMI) &GT;30 kg/m(2), with or without chronic ventilatory failure (awake arterial partial pressure of carbon dioxide >6 kPa or base excess (BE) =2 mmols/L). Factors investigated were grouped into domains: (1) obesity measures, (2) pulmonary function, (3) respiratory and non-respiratory muscle strength, (4) sleep study derivatives, (5) hypoxic and hypercapnic responses, and (6) some hormonal, nutritional and inflammatory measures.</p> <p>RESULTS:</p> 71 obese participants (52% male) were studied over 27 months, 52 (SD 9) years and BMI 47 (range 32-74) kg/m(2). The best univariate correlates of BE from each domain were: (1) dual-energy X-ray absorptiometry measurement of visceral fat (r=+0.50, p=0.001); (2) supine forced expiratory volume in 1 s (r=-0.40, p=0.001); (3) sniff maximum pressure (r=-0.28, p=0.02); (4) mean overnight arterial oxygen saturation (r=-0.50, p&LT;0.001); (5) ventilatory response to 15% O2 breathing (r=-0.28, p=0.02); and (6) vitamin D (r=-0.30, p=0.01). In multivariate analysis, only visceral fat and ventilatory response to hypoxia remained significant. <p>CONCLUSIONS:</p> <p>We have confirmed that in the obese, BMI is a poor correlate of chronic ventilatory failure, and the best independent correlates are visceral fat and hypoxic ventilatory response.</p> |
| first_indexed | 2024-03-06T23:37:02Z |
| format | Thesis |
| id | oxford-uuid:6e02399d-14d3-4601-9e63-0d1e446a2c3c |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:37:02Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | oxford-uuid:6e02399d-14d3-4601-9e63-0d1e446a2c3c2022-03-26T19:21:33ZFactors associated with ventilatory failure in obesityThesishttp://purl.org/coar/resource_type/c_db06uuid:6e02399d-14d3-4601-9e63-0d1e446a2c3cORA Deposit2016Manuel, AStradling, J<p>INTRODUCTION: Only a third of obese patients develop chronic ventilatory failure. This cross-sectional study assessed multiple factors potentially associated with chronic ventilatory failure.</p> <p>MATERIALS/PATIENTS AND METHODS:</p> <p>Participants had a body mass index (BMI) &GT;30 kg/m(2), with or without chronic ventilatory failure (awake arterial partial pressure of carbon dioxide >6 kPa or base excess (BE) =2 mmols/L). Factors investigated were grouped into domains: (1) obesity measures, (2) pulmonary function, (3) respiratory and non-respiratory muscle strength, (4) sleep study derivatives, (5) hypoxic and hypercapnic responses, and (6) some hormonal, nutritional and inflammatory measures.</p> <p>RESULTS:</p> 71 obese participants (52% male) were studied over 27 months, 52 (SD 9) years and BMI 47 (range 32-74) kg/m(2). The best univariate correlates of BE from each domain were: (1) dual-energy X-ray absorptiometry measurement of visceral fat (r=+0.50, p=0.001); (2) supine forced expiratory volume in 1 s (r=-0.40, p=0.001); (3) sniff maximum pressure (r=-0.28, p=0.02); (4) mean overnight arterial oxygen saturation (r=-0.50, p&LT;0.001); (5) ventilatory response to 15% O2 breathing (r=-0.28, p=0.02); and (6) vitamin D (r=-0.30, p=0.01). In multivariate analysis, only visceral fat and ventilatory response to hypoxia remained significant. <p>CONCLUSIONS:</p> <p>We have confirmed that in the obese, BMI is a poor correlate of chronic ventilatory failure, and the best independent correlates are visceral fat and hypoxic ventilatory response.</p> |
| spellingShingle | Manuel, A Factors associated with ventilatory failure in obesity |
| title | Factors associated with ventilatory failure in obesity |
| title_full | Factors associated with ventilatory failure in obesity |
| title_fullStr | Factors associated with ventilatory failure in obesity |
| title_full_unstemmed | Factors associated with ventilatory failure in obesity |
| title_short | Factors associated with ventilatory failure in obesity |
| title_sort | factors associated with ventilatory failure in obesity |
| work_keys_str_mv | AT manuela factorsassociatedwithventilatoryfailureinobesity |