FTO genetic variants and risk of obesity and type 2 diabetes: a meta-analysis of 28,394 Indians.
OBJECTIVE: To investigate the magnitude of association of FTO variants with obesity, type 2 diabetes (T2DM), and related traits among Asian Indians. METHODS: Random-effect meta-analysis was performed on pooled data from eight studies (n = 28,394) for obesity and related traits and six studies (n = 2...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2014
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| _version_ | 1797074527680724992 |
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| author | Vasan, S Karpe, F Gu, H Brismar, K Fall, C Ingelsson, E Fall, T |
| author_facet | Vasan, S Karpe, F Gu, H Brismar, K Fall, C Ingelsson, E Fall, T |
| author_sort | Vasan, S |
| collection | OXFORD |
| description | OBJECTIVE: To investigate the magnitude of association of FTO variants with obesity, type 2 diabetes (T2DM), and related traits among Asian Indians. METHODS: Random-effect meta-analysis was performed on pooled data from eight studies (n = 28,394) for obesity and related traits and six studies (n = 24,987) for assessment of T2DM risk in Indians where FTO variants were reported. RESULTS: The minor A-allele of the FTO variant rs9939609 was associated with increased risk of obesity (OR 1.15, 95% CI 1.08-1.21, p = 2.14 × 10(-) (5) ), BMI (β = 0.30 kg/m2, 95% CI 0.21-0.38, p = 4.78 × 10(-) (11) ) and other regional adiposity measurements [waist (β = 0.74 cm, 95% CI 0.49-0.99), HC (β = 0.52, 95% CI 0.26-0.78), and waist-hip ratio (WHR) (β = 0.002, 95% CI 0.001-0.004)] in Indians (p ≤ 0.001). An increased risk for T2DM (OR 1.11; 95% CI 1.04-1.19, p = 0.002) was observed, which attenuated when adjusted for age, gender, and BMI (OR 1.09; 95%CI 1.02-1.16, p = 0.01). CONCLUSIONS: Our study provides evidence of association between common FTO variant and obesity risk among Indians with comparable effect sizes as in Caucasians. The attenuation of FTO-T2DM risk on BMI adjustment reinforces that BMI does not fully account for the adiposity effects among Asian Indians who are more centrally obese. |
| first_indexed | 2024-03-06T23:37:29Z |
| format | Journal article |
| id | oxford-uuid:6e28d0bf-392d-46d0-ab1e-252ced7fb944 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:37:29Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:6e28d0bf-392d-46d0-ab1e-252ced7fb9442022-03-26T19:22:29ZFTO genetic variants and risk of obesity and type 2 diabetes: a meta-analysis of 28,394 Indians.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6e28d0bf-392d-46d0-ab1e-252ced7fb944EnglishSymplectic Elements at Oxford2014Vasan, SKarpe, FGu, HBrismar, KFall, CIngelsson, EFall, TOBJECTIVE: To investigate the magnitude of association of FTO variants with obesity, type 2 diabetes (T2DM), and related traits among Asian Indians. METHODS: Random-effect meta-analysis was performed on pooled data from eight studies (n = 28,394) for obesity and related traits and six studies (n = 24,987) for assessment of T2DM risk in Indians where FTO variants were reported. RESULTS: The minor A-allele of the FTO variant rs9939609 was associated with increased risk of obesity (OR 1.15, 95% CI 1.08-1.21, p = 2.14 × 10(-) (5) ), BMI (β = 0.30 kg/m2, 95% CI 0.21-0.38, p = 4.78 × 10(-) (11) ) and other regional adiposity measurements [waist (β = 0.74 cm, 95% CI 0.49-0.99), HC (β = 0.52, 95% CI 0.26-0.78), and waist-hip ratio (WHR) (β = 0.002, 95% CI 0.001-0.004)] in Indians (p ≤ 0.001). An increased risk for T2DM (OR 1.11; 95% CI 1.04-1.19, p = 0.002) was observed, which attenuated when adjusted for age, gender, and BMI (OR 1.09; 95%CI 1.02-1.16, p = 0.01). CONCLUSIONS: Our study provides evidence of association between common FTO variant and obesity risk among Indians with comparable effect sizes as in Caucasians. The attenuation of FTO-T2DM risk on BMI adjustment reinforces that BMI does not fully account for the adiposity effects among Asian Indians who are more centrally obese. |
| spellingShingle | Vasan, S Karpe, F Gu, H Brismar, K Fall, C Ingelsson, E Fall, T FTO genetic variants and risk of obesity and type 2 diabetes: a meta-analysis of 28,394 Indians. |
| title | FTO genetic variants and risk of obesity and type 2 diabetes: a meta-analysis of 28,394 Indians. |
| title_full | FTO genetic variants and risk of obesity and type 2 diabetes: a meta-analysis of 28,394 Indians. |
| title_fullStr | FTO genetic variants and risk of obesity and type 2 diabetes: a meta-analysis of 28,394 Indians. |
| title_full_unstemmed | FTO genetic variants and risk of obesity and type 2 diabetes: a meta-analysis of 28,394 Indians. |
| title_short | FTO genetic variants and risk of obesity and type 2 diabetes: a meta-analysis of 28,394 Indians. |
| title_sort | fto genetic variants and risk of obesity and type 2 diabetes a meta analysis of 28 394 indians |
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