E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes.

E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes.

Ubiquitin-conjugating enzymes (E2s) have a dominant role in determining which of the seven lysine residues of ubiquitin is used for polyubiquitination. Here we show that tethering of a substrate to an E2 enzyme in the absence of an E3 ubiquitin ligase is sufficient to promote its ubiquitination, whe...

書誌詳細
主要な著者:	David, Y, Ternette, N, Edelmann, M, Ziv, T, Gayer, B, Sertchook, R, Dadon, Y, Kessler, B, Navon, A
フォーマット:	Journal article
言語:	English
出版事項:	2011

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