Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms.

Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms.

Mice over-expressing the creatine transporter have elevated myocardial creatine levels [Cr] and are protected against ischaemia/reperfusion injury via improved energy reserve. However, mice with very high [Cr] develop cardiac hypertrophy and dysfunction. To investigate these contrasting effects, we...

书目详细资料
Main Authors:	Zervou, S, Yin, X, A Nabeebaccus, A, O'Brien, B, L Cross, R, McAndrew, D, Atkinson, R, Eykyn, T, Mayr, M, Neubauer, S, Lygate, C
格式:	Journal article
语言:	English
出版:	Springer Verlag 2016

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