Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms.

Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms.

Mice over-expressing the creatine transporter have elevated myocardial creatine levels [Cr] and are protected against ischaemia/reperfusion injury via improved energy reserve. However, mice with very high [Cr] develop cardiac hypertrophy and dysfunction. To investigate these contrasting effects, we...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Zervou, S, Yin, X, A Nabeebaccus, A, O'Brien, B, L Cross, R, McAndrew, D, Atkinson, R, Eykyn, T, Mayr, M, Neubauer, S, Lygate, C
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	Springer Verlag 2016

Antzeko izenburuak

Influence of homoarginine on creatine accumulation and biosynthesis in the mouse
nork: Lygate, CA, et al.
Argitaratua: (2022)

Protective effect of creatine elevation against ischaemia reperfusion injury is retained in the presence of co-morbidities and during cardioplegia.
nork: Whittington, H, et al.
Argitaratua: (2016)

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart
nork: Aksentijević, D, et al.
Argitaratua: (2014)

Influence of homoarginine on creatine accumulation and biosynthesis in the mouse
nork: Craig A. Lygate, et al.
Argitaratua: (2022-08-01)

Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure
nork: McAndrew, DJ, et al.
Argitaratua: (2022)

Protective Effect of Creatine Elevation against Ischaemia Reperfusion Injury Is Retained in the Presence of Co-Morbidities and during Cardioplegia.
nork: Hannah J Whittington, et al.
Argitaratua: (2016-01-01)

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.
nork: Lygate, C, et al.
Argitaratua: (2012)

Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion
nork: Whittington, H, et al.
Argitaratua: (2018)

Creatine reduces mitochondrial permeability transition pore opening in response to oxidative stress in vitro
nork: Zervou, S, et al.
Argitaratua: (2010)

The creatine kinase system as a therapeutic target for myocardial ischaemia-reperfusion injury
nork: Cao, F, et al.
Argitaratua: (2018)

Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure
nork: Cao, F, et al.
Argitaratua: (2020)

Elevated Myocardial Creatine Protects Against Ischemia/Reperfusion Injury by Improving Cardiac Energetics
nork: Lygate, C, et al.
Argitaratua: (2011)

A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis.
nork: Zervou, S, et al.
Argitaratua: (2013)

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart.
nork: Dunja Aksentijević, et al.
Argitaratua: (2014-01-01)

REGULATION OF CELLULAR CREATINE HOMEOSTASIS: A ROLE FOR THIOREDOXIN INTERACTING PROTEIN (TXNIP)
nork: Zervou, S, et al.
Argitaratua: (2013)

Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure
nork: Debra J. McAndrew, et al.
Argitaratua: (2023-02-01)

Synergistic effect on cardiac energetics by targeting the creatine kinase system: in vivo application of high-resolution 31P-CMRS in the mouse
nork: Maguire, ML, et al.
Argitaratua: (2023)

Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine
nork: Faller, K, et al.
Argitaratua: (2017)

Chronic Creatine-deficiency is not the Underlying Cause of Cardiac Dysfunction in Mice Lacking the Creatine Biosynthetic Enzyme Arginine: glycine Amidinotransferase
nork: Lygate, C, et al.
Argitaratua: (2013)

Age-dependent decline in cardiac function in guanidinoacetate-N-methyltransferase knockout mice
nork: Aksentijević, D, et al.
Argitaratua: (2019)

Regulation of Myocardial Creatine Uptake by Intra- and Extracellular Creatine Levels
nork: Makinen, K, et al.
Argitaratua: (2008)

Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice
nork: Lygate, C, et al.
Argitaratua: (2013)

Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
nork: Lygate, C, et al.
Argitaratua: (2013)

Augmentation of creatine kinase in vitro protects against simulated ischaemia reperfusion injury
nork: Zervou, S, et al.
Argitaratua: (2017)

Screening for small molecule regulators of the creatine transporter (SLC6A8)
nork: Zervou, S, et al.
Argitaratua: (2020)

Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro
nork: Zervou, S, et al.
Argitaratua: (2017)

Synergistic effect on cardiac energetics by targeting the creatine kinase system: in vivo application of high-resolution 31P-CMRS in the mouse
nork: Mahon L. Maguire, et al.
Argitaratua: (2023-02-01)

New insights into the creatine kinase-phosphocreatine energy buffer and transport system using mouse models of altered creatine content
nork: Lygate, C, et al.
Argitaratua: (2006)

Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice
nork: Dunja Aksentijević, et al.
Argitaratua: (2020-01-01)

Creatine uptake in mouse hearts with genetically altered creatine levels.
nork: ten Hove, M, et al.
Argitaratua: (2008)

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age
nork: Lygate, C, et al.
Argitaratua: (2012)

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age.
nork: Lygate, C, et al.
Argitaratua: (2012)

1H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism
nork: Faller, K, et al.
Argitaratua: (2013)

(1)H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism.
nork: Faller, K, et al.
Argitaratua: (2013)

Subtle role for adenylate kinase 1 in maintaining normal basal contractile function and metabolism in the murine heart
nork: Zervou, S, et al.
Argitaratua: (2021)

Ribose supplementation alone or with elevated creatine does not preserve high energy nucleotides or cardiac function in the failing mouse heart
nork: Faller, K, et al.
Argitaratua: (2013)

Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.
nork: Sevasti Zervou, et al.
Argitaratua: (2017-01-01)

Myocardial creatine uptake is regulated by the sarcolemmal fraction of the creatine transporter, but not by the total creatine transporter pool
nork: Boehm, E, et al.
Argitaratua: (2002)

The creatine kinase energy transport system in the failing mouse heart
nork: Lygate, C, et al.
Argitaratua: (2006)

Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure
nork: Atzler, D, et al.
Argitaratua: (2017)