Contribution to malaria transmission of symptomatic and asymptomatic parasite carriers in Cambodia
Eliminating falciparum malaria in Cambodia is a top priority, requiring the implementation of novel tools and strategies to interrupt its transmission. To date, few data are available regarding the contributions to malaria transmission of symptomatic and asymptomatic carriers.Direct-membrane and ski...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2018
|
| _version_ | 1797074626490138624 |
|---|---|
| author | Vantaux, A Samreth, R Piv, E Khim, N Kim, S Berne, L Chy, S Lek, D Siv, S Taylor, W Ménard, D |
| author_facet | Vantaux, A Samreth, R Piv, E Khim, N Kim, S Berne, L Chy, S Lek, D Siv, S Taylor, W Ménard, D |
| author_sort | Vantaux, A |
| collection | OXFORD |
| description | Eliminating falciparum malaria in Cambodia is a top priority, requiring the implementation of novel tools and strategies to interrupt its transmission. To date, few data are available regarding the contributions to malaria transmission of symptomatic and asymptomatic carriers.Direct-membrane and skin feeding assays (DMFAs, SFAs) were performed, using Anopheles minimus and Anopheles dirus, to determine infectivity of symptomatic falciparum-infected patients and malaria asymptomatic carriers; a subset of the latter were followed up for 2 months to assess their transmission potential.By microscopy and real-time polymerase chain reaction, Plasmodium falciparum gametocyte prevalence rates were, respectively, 19.3% (n = 21/109) and 44% (n = 47/109) on day (D) 0 and 17.9% (n = 5/28) and 89.3% (n = 25/28) in recrudescent patients (Drec) (RT-PCR Drec vs D0 P = .002). Falciparum malaria patient infectivity was low on D0 (6.2%; n = 3/48) and in Drec (8.3%; n = 1/12). Direct-membrane feeding assays and SFAs gave similar results. None of the falciparum (n = 0/19) and 3 of 28 Plasmodium vivax asymptomatic carriers were infectious to mosquitoes, including those that were followed up for 2 months. Overall, P. falciparum gametocytemias were low except in a few symptomatic carriers.Only symptomatic falciparum malaria patients were infectious to mosquito vectors at baseline and recrudescence, highlighting the need to detect promptly and treat effectively P. falciparum patients. |
| first_indexed | 2024-03-06T23:38:57Z |
| format | Journal article |
| id | oxford-uuid:6ea16881-120d-4725-9b87-ad1350017089 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:38:57Z |
| publishDate | 2018 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:6ea16881-120d-4725-9b87-ad13500170892022-03-26T19:25:43ZContribution to malaria transmission of symptomatic and asymptomatic parasite carriers in CambodiaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6ea16881-120d-4725-9b87-ad1350017089EnglishSymplectic Elements at OxfordOxford University Press2018Vantaux, ASamreth, RPiv, EKhim, NKim, SBerne, LChy, SLek, DSiv, STaylor, WMénard, DEliminating falciparum malaria in Cambodia is a top priority, requiring the implementation of novel tools and strategies to interrupt its transmission. To date, few data are available regarding the contributions to malaria transmission of symptomatic and asymptomatic carriers.Direct-membrane and skin feeding assays (DMFAs, SFAs) were performed, using Anopheles minimus and Anopheles dirus, to determine infectivity of symptomatic falciparum-infected patients and malaria asymptomatic carriers; a subset of the latter were followed up for 2 months to assess their transmission potential.By microscopy and real-time polymerase chain reaction, Plasmodium falciparum gametocyte prevalence rates were, respectively, 19.3% (n = 21/109) and 44% (n = 47/109) on day (D) 0 and 17.9% (n = 5/28) and 89.3% (n = 25/28) in recrudescent patients (Drec) (RT-PCR Drec vs D0 P = .002). Falciparum malaria patient infectivity was low on D0 (6.2%; n = 3/48) and in Drec (8.3%; n = 1/12). Direct-membrane feeding assays and SFAs gave similar results. None of the falciparum (n = 0/19) and 3 of 28 Plasmodium vivax asymptomatic carriers were infectious to mosquitoes, including those that were followed up for 2 months. Overall, P. falciparum gametocytemias were low except in a few symptomatic carriers.Only symptomatic falciparum malaria patients were infectious to mosquito vectors at baseline and recrudescence, highlighting the need to detect promptly and treat effectively P. falciparum patients. |
| spellingShingle | Vantaux, A Samreth, R Piv, E Khim, N Kim, S Berne, L Chy, S Lek, D Siv, S Taylor, W Ménard, D Contribution to malaria transmission of symptomatic and asymptomatic parasite carriers in Cambodia |
| title | Contribution to malaria transmission of symptomatic and asymptomatic parasite carriers in Cambodia |
| title_full | Contribution to malaria transmission of symptomatic and asymptomatic parasite carriers in Cambodia |
| title_fullStr | Contribution to malaria transmission of symptomatic and asymptomatic parasite carriers in Cambodia |
| title_full_unstemmed | Contribution to malaria transmission of symptomatic and asymptomatic parasite carriers in Cambodia |
| title_short | Contribution to malaria transmission of symptomatic and asymptomatic parasite carriers in Cambodia |
| title_sort | contribution to malaria transmission of symptomatic and asymptomatic parasite carriers in cambodia |
| work_keys_str_mv | AT vantauxa contributiontomalariatransmissionofsymptomaticandasymptomaticparasitecarriersincambodia AT samrethr contributiontomalariatransmissionofsymptomaticandasymptomaticparasitecarriersincambodia AT pive contributiontomalariatransmissionofsymptomaticandasymptomaticparasitecarriersincambodia AT khimn contributiontomalariatransmissionofsymptomaticandasymptomaticparasitecarriersincambodia AT kims contributiontomalariatransmissionofsymptomaticandasymptomaticparasitecarriersincambodia AT bernel contributiontomalariatransmissionofsymptomaticandasymptomaticparasitecarriersincambodia AT chys contributiontomalariatransmissionofsymptomaticandasymptomaticparasitecarriersincambodia AT lekd contributiontomalariatransmissionofsymptomaticandasymptomaticparasitecarriersincambodia AT sivs contributiontomalariatransmissionofsymptomaticandasymptomaticparasitecarriersincambodia AT taylorw contributiontomalariatransmissionofsymptomaticandasymptomaticparasitecarriersincambodia AT menardd contributiontomalariatransmissionofsymptomaticandasymptomaticparasitecarriersincambodia |