Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis
<strong>Objectives</strong> The neural activity of the primary motor cortex is variably synchronised with contralateral peripheral electromyographic signals, which is thought to facilitate long-range communication through the motor system. Such corticomuscular coherence (CMC) is typicall...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Published: |
Elsevier
2018
|
| _version_ | 1826278142330798080 |
|---|---|
| author | Proudfoot, M van Ede, F Quinn, A Colclough, G Wuu, J Talbot, K Benatar, M Woolrich, M Nobre, A Turner, M |
| author_facet | Proudfoot, M van Ede, F Quinn, A Colclough, G Wuu, J Talbot, K Benatar, M Woolrich, M Nobre, A Turner, M |
| author_sort | Proudfoot, M |
| collection | OXFORD |
| description | <strong>Objectives</strong> The neural activity of the primary motor cortex is variably synchronised with contralateral peripheral electromyographic signals, which is thought to facilitate long-range communication through the motor system. Such corticomuscular coherence (CMC) is typically observed in the beta-band (15–30 Hz) range during steady force production. We aimed to measure pathological alteration to CMC resulting from ALS. <strong>Methods</strong> CMC was appraised during a forearm grip task in 17 ALS patients contrasted against age-matched healthy controls. An exploratory comparison with a group of asymptomatic ALS gene carriers and neuropathy disease mimics was also undertaken. Neural signals were acquired by whole-head magnetoencephalography and localised via structural MRI to the motor cortices. <strong>Results</strong> During light voluntary muscular contraction, beta-band CMC was significantly reduced in ALS patients compared to healthy controls. Propagation of motoric beta rhythms across the cortical hemispheres was also shown to be impaired in ALS patients. CMC was preserved in the asymptomatic gene carrier and did not distinguish ALS patients from neuropathy mimics. <strong>Conclusion</strong> Functional connectivity metrics reveal an ALS-related decrease in both corticomuscular and interhemispheric communication during bilateral grip force production. |
| first_indexed | 2024-03-06T23:39:31Z |
| format | Journal article |
| id | oxford-uuid:6ecfd94b-464d-4f16-9a75-60106bb0b44f |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:39:31Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:6ecfd94b-464d-4f16-9a75-60106bb0b44f2022-03-26T19:26:52ZImpaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6ecfd94b-464d-4f16-9a75-60106bb0b44fSymplectic Elements at OxfordElsevier2018Proudfoot, Mvan Ede, FQuinn, AColclough, GWuu, JTalbot, KBenatar, MWoolrich, MNobre, ATurner, M<strong>Objectives</strong> The neural activity of the primary motor cortex is variably synchronised with contralateral peripheral electromyographic signals, which is thought to facilitate long-range communication through the motor system. Such corticomuscular coherence (CMC) is typically observed in the beta-band (15–30 Hz) range during steady force production. We aimed to measure pathological alteration to CMC resulting from ALS. <strong>Methods</strong> CMC was appraised during a forearm grip task in 17 ALS patients contrasted against age-matched healthy controls. An exploratory comparison with a group of asymptomatic ALS gene carriers and neuropathy disease mimics was also undertaken. Neural signals were acquired by whole-head magnetoencephalography and localised via structural MRI to the motor cortices. <strong>Results</strong> During light voluntary muscular contraction, beta-band CMC was significantly reduced in ALS patients compared to healthy controls. Propagation of motoric beta rhythms across the cortical hemispheres was also shown to be impaired in ALS patients. CMC was preserved in the asymptomatic gene carrier and did not distinguish ALS patients from neuropathy mimics. <strong>Conclusion</strong> Functional connectivity metrics reveal an ALS-related decrease in both corticomuscular and interhemispheric communication during bilateral grip force production. |
| spellingShingle | Proudfoot, M van Ede, F Quinn, A Colclough, G Wuu, J Talbot, K Benatar, M Woolrich, M Nobre, A Turner, M Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis |
| title | Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis |
| title_full | Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis |
| title_fullStr | Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis |
| title_full_unstemmed | Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis |
| title_short | Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis |
| title_sort | impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis |
| work_keys_str_mv | AT proudfootm impairedcorticomuscularandinterhemisphericcorticalbetaoscillationcouplinginamyotrophiclateralsclerosis AT vanedef impairedcorticomuscularandinterhemisphericcorticalbetaoscillationcouplinginamyotrophiclateralsclerosis AT quinna impairedcorticomuscularandinterhemisphericcorticalbetaoscillationcouplinginamyotrophiclateralsclerosis AT colcloughg impairedcorticomuscularandinterhemisphericcorticalbetaoscillationcouplinginamyotrophiclateralsclerosis AT wuuj impairedcorticomuscularandinterhemisphericcorticalbetaoscillationcouplinginamyotrophiclateralsclerosis AT talbotk impairedcorticomuscularandinterhemisphericcorticalbetaoscillationcouplinginamyotrophiclateralsclerosis AT benatarm impairedcorticomuscularandinterhemisphericcorticalbetaoscillationcouplinginamyotrophiclateralsclerosis AT woolrichm impairedcorticomuscularandinterhemisphericcorticalbetaoscillationcouplinginamyotrophiclateralsclerosis AT nobrea impairedcorticomuscularandinterhemisphericcorticalbetaoscillationcouplinginamyotrophiclateralsclerosis AT turnerm impairedcorticomuscularandinterhemisphericcorticalbetaoscillationcouplinginamyotrophiclateralsclerosis |