Susceptibility to Theiler's virus-induced demyelinating disease correlates with astrocyte class II induction and antigen presentation.
Theiler's murine encephalomyelitis virus (TMEV) is a picornavirus which induces a chronic demyelinating disease of the central nervous system (CNS) in certain susceptible mouse strains. Demyelination has been shown to result from immunopathological responses mediated by CD4+, major histocompati...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1992
|
| _version_ | 1826278172148105216 |
|---|---|
| author | Borrow, P Nash, A |
| author_facet | Borrow, P Nash, A |
| author_sort | Borrow, P |
| collection | OXFORD |
| description | Theiler's murine encephalomyelitis virus (TMEV) is a picornavirus which induces a chronic demyelinating disease of the central nervous system (CNS) in certain susceptible mouse strains. Demyelination has been shown to result from immunopathological responses mediated by CD4+, major histocompatibility complex (MHC) class II-restricted T cells. As little or no class II is expressed in the normal mouse CNS, the ability of astrocytes to express these proteins and present antigen to T cells from TMEV-infected mice was investigated here. It is shown that astrocytes are capable of presenting TMEV to virus-specific T cells in vitro, and that this ability is dependent on prior induction of MHC class II by interferon-gamma (IFN-gamma) treatment. Unlike other viruses such as murine hepatitis virus-JHM (a coronavirus) and measles, TMEV is not capable of inducing class II on astrocytes directly. There is a correlation between the ease of class II induction on astrocytes from different mouse strains by IFN-gamma and mouse strain susceptibility to TMEV-induced demyelinating disease. These results suggest that following viral infection and initial T-cell infiltration into the CNS, class II induction on astrocytes is a key step allowing local antigen presentation and amplification of immunopathological responses within the CNS and hence the development of demyelinating disease. |
| first_indexed | 2024-03-06T23:39:58Z |
| format | Journal article |
| id | oxford-uuid:6ef5c82f-5c28-4ba7-b553-46589ae3aab3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:39:58Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:6ef5c82f-5c28-4ba7-b553-46589ae3aab32022-03-26T19:27:48ZSusceptibility to Theiler's virus-induced demyelinating disease correlates with astrocyte class II induction and antigen presentation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6ef5c82f-5c28-4ba7-b553-46589ae3aab3EnglishSymplectic Elements at Oxford1992Borrow, PNash, ATheiler's murine encephalomyelitis virus (TMEV) is a picornavirus which induces a chronic demyelinating disease of the central nervous system (CNS) in certain susceptible mouse strains. Demyelination has been shown to result from immunopathological responses mediated by CD4+, major histocompatibility complex (MHC) class II-restricted T cells. As little or no class II is expressed in the normal mouse CNS, the ability of astrocytes to express these proteins and present antigen to T cells from TMEV-infected mice was investigated here. It is shown that astrocytes are capable of presenting TMEV to virus-specific T cells in vitro, and that this ability is dependent on prior induction of MHC class II by interferon-gamma (IFN-gamma) treatment. Unlike other viruses such as murine hepatitis virus-JHM (a coronavirus) and measles, TMEV is not capable of inducing class II on astrocytes directly. There is a correlation between the ease of class II induction on astrocytes from different mouse strains by IFN-gamma and mouse strain susceptibility to TMEV-induced demyelinating disease. These results suggest that following viral infection and initial T-cell infiltration into the CNS, class II induction on astrocytes is a key step allowing local antigen presentation and amplification of immunopathological responses within the CNS and hence the development of demyelinating disease. |
| spellingShingle | Borrow, P Nash, A Susceptibility to Theiler's virus-induced demyelinating disease correlates with astrocyte class II induction and antigen presentation. |
| title | Susceptibility to Theiler's virus-induced demyelinating disease correlates with astrocyte class II induction and antigen presentation. |
| title_full | Susceptibility to Theiler's virus-induced demyelinating disease correlates with astrocyte class II induction and antigen presentation. |
| title_fullStr | Susceptibility to Theiler's virus-induced demyelinating disease correlates with astrocyte class II induction and antigen presentation. |
| title_full_unstemmed | Susceptibility to Theiler's virus-induced demyelinating disease correlates with astrocyte class II induction and antigen presentation. |
| title_short | Susceptibility to Theiler's virus-induced demyelinating disease correlates with astrocyte class II induction and antigen presentation. |
| title_sort | susceptibility to theiler s virus induced demyelinating disease correlates with astrocyte class ii induction and antigen presentation |
| work_keys_str_mv | AT borrowp susceptibilitytotheilersvirusinduceddemyelinatingdiseasecorrelateswithastrocyteclassiiinductionandantigenpresentation AT nasha susceptibilitytotheilersvirusinduceddemyelinatingdiseasecorrelateswithastrocyteclassiiinductionandantigenpresentation |