Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia

Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia

Altered metabolism is a hallmark of cancer. However, the role of genomic changes in metabolic genes driving the tumour metabolic shift remains to be elucidated. Here, we have investigated the genomic and transcriptomic changes underlying this shift across ten different cancer types.A systematic pan-...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Haider, S, McIntyre, A, van Stiphout, R, Winchester, L, Wigfield, S, Harris, A, Buffa, F
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	BioMed Central 2016

Παρόμοια τεκμήρια

The tumour hypoxia induced non-coding transcriptome.
ανά: Choudhry, H, κ.ά.
Έκδοση: (2016)

Gene expression signatures as biomarkers of tumour hypoxia
ανά: Harris, B, κ.ά.
Έκδοση: (2015)

Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis.
ανά: Jubb, A, κ.ά.
Έκδοση: (2010)

The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer (TNBC)
ανά: Harris, A, κ.ά.
Έκδοση: (2016)

Metabolic Shift and Hyperosmolarity Underlie Age-Related Macular Degeneration
ανά: Laurent Schwartz, κ.ά.
Έκδοση: (2024-09-01)

Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes
ανά: Jeremy R. B. Newman, κ.ά.
Έκδοση: (2023-09-01)

Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors
ανά: Dhawan, A, κ.ά.
Έκδοση: (2018)

Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype.
ανά: Ameri, K, κ.ά.
Έκδοση: (2010)

Pan-cancer characterisation of microRNA with hallmarks of cancer reveals role of microRNA-mediated downregulation of tumour suppressor genes
ανά: Dhawan, A, κ.ά.
Έκδοση: (2018)

Proline-hydroxylated hypoxia-inducible factor 1a (HIF-1a) upregulation in human tumours
ανά: Snell, C, κ.ά.
Έκδοση: (2014)

Targeting tumour hypoxia in breast cancer.
ανά: Milani, M, κ.ά.
Έκδοση: (2008)

Defining the role of AP1 in molecular adaptation to hypoxia in colorectal cancer
ανά: Vancauwenberghe, E, κ.ά.
Έκδοση: (2019)

Methyl Sulfone Blocked Multiple Hypoxia- and Non-Hypoxia-Induced Metastatic Targets in Breast Cancer Cells and Melanoma Cells.
ανά: Joan McIntyre Caron, κ.ά.
Έκδοση: (2015-01-01)

Targeting tumour hypoxia: shifting focus from oxygen supply to demand
ανά: Coates, J, κ.ά.
Έκδοση: (2018)

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer
ανά: Morotti, M, κ.ά.
Έκδοση: (2019)

Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors
ανά: Andrew Dhawan, κ.ά.
Έκδοση: (2018-12-01)

Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours.
ανά: Cameron E Snell, κ.ά.
Έκδοση: (2014-01-01)

Editorial: Bottom-Up and Top-Down: Molecules and Circuits That Underlie Chemosensory Behaviors
ανά: Pablo Chamero, κ.ά.
Έκδοση: (2021-08-01)

Disrupting hypoxia-induced bicarbonate transport acidifies tumor cells and suppresses tumor growth
ανά: McIntyre, A, κ.ά.
Έκδοση: (2016)

Regulation of autophagy by ATF4 in response to severe hypoxia.
ανά: Rzymski, T, κ.ά.
Έκδοση: (2010)

Gene expression and hypoxia in breast cancer.
ανά: Favaro, E, κ.ά.
Έκδοση: (2011)

Integrated analysis of metabolite and transcript levels reveals the metabolic shifts that underlie tomato fruit development and highlight regulatory aspects of metabolic network behavior.
ανά: Carrari, F, κ.ά.
Έκδοση: (2006)

Survival Pathways of HIF-Deficient Tumour Cells: TCA Inhibition, Peroxisomal Fatty Acid Oxidation Activation and an AMPK-PGC-1α Hypoxia Sensor
ανά: Monika A. Golinska, κ.ά.
Έκδοση: (2022-11-01)

Transmission shifts underlie variability in population responses to Yersinia pestis infection.
ανά: Michael G Buhnerkempe, κ.ά.
Έκδοση: (2011-01-01)

Heterochronic developmental shifts underlie floral diversity within Jaltomata (Solanaceae)
ανά: Jamie L. Kostyun, κ.ά.
Έκδοση: (2017-10-01)

Pan-cancer analysis of tumor metabolic landscape associated with genomic alterations
ανά: Hongyoon Choi, κ.ά.
Έκδοση: (2018-10-01)

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
ανά: Ashton, T, κ.ά.
Έκδοση: (2016)

Cancer-associated, hypoxia-inducible carbonic anhydrase IX facilitates CO2 diffusion.
ανά: Swietach, P, κ.ά.
Έκδοση: (2008)

Pan-genomic binding of hypoxia-inducible transcription factors.
ανά: Schödel, J, κ.ά.
Έκδοση: (2013)

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer.
ανά: Wigfield, S, κ.ά.
Έκδοση: (2008)

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
ανά: Thomas M. Ashton, κ.ά.
Έκδοση: (2016-07-01)

Proteomic alterations underlie an association with teratozoospermia in obese mice sperm
ανά: Yuanhong Peng, κ.ά.
Έκδοση: (2019-10-01)

Shifts in morphology, gene expression, and selection underlie web loss in Hawaiian Tetragnatha spiders
ανά: Cory A. Berger, κ.ά.
Έκδοση: (2021-03-01)

Positive and negative emotions underlie motivation for L2 learning
ανά: Peter D. MacIntyre, κ.ά.
Έκδοση: (2017-03-01)

Stepwise shifts underlie evolutionary trends in morphological complexity of the mammalian vertebral column
ανά: Katrina E. Jones, κ.ά.
Έκδοση: (2019-11-01)

The role of hypoxia regulated microRNAs in cancer.
ανά: McCormick, R, κ.ά.
Έκδοση: (2010)

Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation.
ανά: Jones, D, κ.ά.
Έκδοση: (2006)

Altered myogenesis and premature senescence underlie human TRIM32-related myopathy
ανά: E. Servián-Morilla, κ.ά.
Έκδοση: (2019-03-01)

Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer
ανά: Blick, C, κ.ά.
Έκδοση: (2013)

Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer.
ανά: Blick, C, κ.ά.
Έκδοση: (2013)