Increasing the nonlinear character of microbubble oscillations at low acoustic pressures.
The nonlinear response of gas bubbles to acoustic excitation is an important phenomenon in both the biomedical and engineering sciences. In medical ultrasound imaging, for example, microbubbles are used as contrast agents on account of their ability to scatter ultrasound nonlinearly. Increasing the...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1826278198814441472 |
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| author | Stride, E Pancholi, K Edirisinghe, M Samarasinghe, S |
| author_facet | Stride, E Pancholi, K Edirisinghe, M Samarasinghe, S |
| author_sort | Stride, E |
| collection | OXFORD |
| description | The nonlinear response of gas bubbles to acoustic excitation is an important phenomenon in both the biomedical and engineering sciences. In medical ultrasound imaging, for example, microbubbles are used as contrast agents on account of their ability to scatter ultrasound nonlinearly. Increasing the degree of nonlinearity, however, normally requires an increase in the amplitude of excitation, which may also result in violent behaviour such as inertial cavitation and bubble fragmentation. These effects may be highly undesirable, particularly in biomedical applications, and the aim of this work was to investigate alternative means of enhancing nonlinear behaviour. In this preliminary report, it is shown through theoretical simulation and experimental verification that depositing nanoparticles on the surface of a bubble increases the nonlinear character of its response significantly at low excitation amplitudes. This is due to the fact that close packing of the nanoparticles restricts bubble compression. |
| first_indexed | 2024-03-06T23:40:22Z |
| format | Journal article |
| id | oxford-uuid:6f19d3ae-225c-4d5b-80ff-36d03f080a10 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:40:22Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:6f19d3ae-225c-4d5b-80ff-36d03f080a102022-03-26T19:28:36ZIncreasing the nonlinear character of microbubble oscillations at low acoustic pressures.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6f19d3ae-225c-4d5b-80ff-36d03f080a10EnglishSymplectic Elements at Oxford2008Stride, EPancholi, KEdirisinghe, MSamarasinghe, SThe nonlinear response of gas bubbles to acoustic excitation is an important phenomenon in both the biomedical and engineering sciences. In medical ultrasound imaging, for example, microbubbles are used as contrast agents on account of their ability to scatter ultrasound nonlinearly. Increasing the degree of nonlinearity, however, normally requires an increase in the amplitude of excitation, which may also result in violent behaviour such as inertial cavitation and bubble fragmentation. These effects may be highly undesirable, particularly in biomedical applications, and the aim of this work was to investigate alternative means of enhancing nonlinear behaviour. In this preliminary report, it is shown through theoretical simulation and experimental verification that depositing nanoparticles on the surface of a bubble increases the nonlinear character of its response significantly at low excitation amplitudes. This is due to the fact that close packing of the nanoparticles restricts bubble compression. |
| spellingShingle | Stride, E Pancholi, K Edirisinghe, M Samarasinghe, S Increasing the nonlinear character of microbubble oscillations at low acoustic pressures. |
| title | Increasing the nonlinear character of microbubble oscillations at low acoustic pressures. |
| title_full | Increasing the nonlinear character of microbubble oscillations at low acoustic pressures. |
| title_fullStr | Increasing the nonlinear character of microbubble oscillations at low acoustic pressures. |
| title_full_unstemmed | Increasing the nonlinear character of microbubble oscillations at low acoustic pressures. |
| title_short | Increasing the nonlinear character of microbubble oscillations at low acoustic pressures. |
| title_sort | increasing the nonlinear character of microbubble oscillations at low acoustic pressures |
| work_keys_str_mv | AT stridee increasingthenonlinearcharacterofmicrobubbleoscillationsatlowacousticpressures AT pancholik increasingthenonlinearcharacterofmicrobubbleoscillationsatlowacousticpressures AT edirisinghem increasingthenonlinearcharacterofmicrobubbleoscillationsatlowacousticpressures AT samarasinghes increasingthenonlinearcharacterofmicrobubbleoscillationsatlowacousticpressures |