Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region.
Somatic interstitial deletions of chromosome segment 7q22-q31 in uterine leiomyomas are a frequent event, thought to be indicative of a tumor suppressor gene in the region. Previous LOH and CGH studies have refined this region to 7q22.3-q31, although the target gene has not been identified. Here, we...
主要な著者: | Vanharanta, S, Wortham, N, Langford, C, El-Bahrawy, M, van der Spuy, Z, Sjöberg, J, Lehtonen, R, Karhu, A, Tomlinson, I, Aaltonen, L |
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フォーマット: | Journal article |
言語: | English |
出版事項: |
2007
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