Difference between random and imprinted X inactivation in common voles.
During early development in female mammals, most genes on one of the two X-chromosomes undergo transcriptional silencing. In the extraembryonic lineages of some eutherian species, imprinted X-inactivation of the paternal X-chromosome occurs. In the cells of the embryo proper, the choice of the futur...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797074781072261120 |
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| author | Dementyeva, E Shevchenko, A Anopriyenko, O Mazurok, N Elisaphenko, E Nesterova, T Brockdorff, N Zakian, S |
| author_facet | Dementyeva, E Shevchenko, A Anopriyenko, O Mazurok, N Elisaphenko, E Nesterova, T Brockdorff, N Zakian, S |
| author_sort | Dementyeva, E |
| collection | OXFORD |
| description | During early development in female mammals, most genes on one of the two X-chromosomes undergo transcriptional silencing. In the extraembryonic lineages of some eutherian species, imprinted X-inactivation of the paternal X-chromosome occurs. In the cells of the embryo proper, the choice of the future inactive X-chromosome is random. We mapped several genes on the X-chromosomes of five common vole species and compared their expression and methylation patterns in somatic and extraembryonic tissues, where random and imprinted X-inactivation occurs, respectively. In extraembryonic tissues, more genes were expressed on the inactive X-chromosome than in somatic tissues. We also found that the methylation status of the X-linked genes was always in accordance with their expression pattern in somatic, but not in extraembryonic tissues. The data provide new evidence that imprinted X-inactivation is less complete and/or stable than the random form and DNA methylation contributes less to its maintenance. |
| first_indexed | 2024-03-06T23:41:09Z |
| format | Journal article |
| id | oxford-uuid:6f5a1527-f879-41bb-ba7d-b02154210d4b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:41:09Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:6f5a1527-f879-41bb-ba7d-b02154210d4b2022-03-26T19:30:11ZDifference between random and imprinted X inactivation in common voles.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6f5a1527-f879-41bb-ba7d-b02154210d4bEnglishSymplectic Elements at Oxford2010Dementyeva, EShevchenko, AAnopriyenko, OMazurok, NElisaphenko, ENesterova, TBrockdorff, NZakian, SDuring early development in female mammals, most genes on one of the two X-chromosomes undergo transcriptional silencing. In the extraembryonic lineages of some eutherian species, imprinted X-inactivation of the paternal X-chromosome occurs. In the cells of the embryo proper, the choice of the future inactive X-chromosome is random. We mapped several genes on the X-chromosomes of five common vole species and compared their expression and methylation patterns in somatic and extraembryonic tissues, where random and imprinted X-inactivation occurs, respectively. In extraembryonic tissues, more genes were expressed on the inactive X-chromosome than in somatic tissues. We also found that the methylation status of the X-linked genes was always in accordance with their expression pattern in somatic, but not in extraembryonic tissues. The data provide new evidence that imprinted X-inactivation is less complete and/or stable than the random form and DNA methylation contributes less to its maintenance. |
| spellingShingle | Dementyeva, E Shevchenko, A Anopriyenko, O Mazurok, N Elisaphenko, E Nesterova, T Brockdorff, N Zakian, S Difference between random and imprinted X inactivation in common voles. |
| title | Difference between random and imprinted X inactivation in common voles. |
| title_full | Difference between random and imprinted X inactivation in common voles. |
| title_fullStr | Difference between random and imprinted X inactivation in common voles. |
| title_full_unstemmed | Difference between random and imprinted X inactivation in common voles. |
| title_short | Difference between random and imprinted X inactivation in common voles. |
| title_sort | difference between random and imprinted x inactivation in common voles |
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