Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.

Show other versions (2)

Human embryonic stem cell-derived cardiomyocytes (hESC-CM) have been proposed as a new model for safety pharmacology. So far, a thorough description of their basic electrophysiology and extensive testing, and mechanistic explanations, of their overall pro-arrhythmic ability is lacking. Under standar...

Full description

Bibliographic Details
Main Authors:	Jonsson, M, Vos, M, Mirams, G, Duker, G, Sartipy, P, de Boer, T, van Veen, T
Format:	Journal article
Language:	English
Published:	2012

Similar Items

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG
by: Jonsson, M, et al.
Published: (2012)

Application of Human Stem Cell−derived Cardiomyocytes in Safety Pharmacology Requires Caution Beyond hERG
by: Jonsson, M, et al.
Published: (2012)

Mathematical modelling of hERG channel kinetics using sinusoidal voltage protocols
by: Beattie, K, et al.
Published: (2017)

The effect of isoliquiritigenin on the hERG potassium channel
by: Mujahid, M, et al.
Published: (2020)

Rapid characterisation of hERG channel kinetics II: temperature dependence
by: Lei, CL, et al.
Published: (2019)

A population of in silico models to face the variability of human induced pluripotent stem cell-derived cardiomyocytes: the hERG block case study
by: Paci, M, et al.
Published: (2017)

Rapid characterisation of hERG channel kinetics I: using an automated high-throughput system
by: Lei, CL, et al.
Published: (2019)

Data on the construction of a recombinant HEK293 cell line overexpressing hERG potassium channel and examining the presence of hERG mRNA and protein expression
by: Yi, Fan Teah, et al.
Published: (2017)

Purification and structural characterization of the voltage-sensor domain of the hERG potassium channel
by: Ng, Hui Qi, et al.
Published: (2013)

Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment
by: Farm, HJ, et al.
Published: (2023)

Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel
by: Li, Qingxin, et al.
Published: (2016)

The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells
by: Pillozzi, Serena, et al.
Published: (2020)

Modeling oxygen requirements in ischemic cardiomyocytes
by: McDougal, Anthony Drew
Published: (2015)

Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes
by: Lopez, C, et al.
Published: (2021)

Inferring public interest from search engine data requires caution
by: Correia, R, et al.
Published: (2019)

Experts call for caution
by: Tang, Ashley
Published: (2021)

Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: An in silico approach
by: Paci, M, et al.
Published: (2017)

'Exercise caution on the road this raya'
by: Daim, Nuradzimmah
Published: (2022)

Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology
by: Lei, C, et al.
Published: (2017)

Differentiation of Embryonic Stem Cells into Cardiomyocytes in a Microfluidic System
by: Wan, Chen-Rei, et al.
Published: (2012)

Effects of oxygen on embryonic stem proliferation, energetics, and differentiation into cardiomyocytes
by: Powers, Daryl E
Published: (2008)

Metabolic maturation of induced pluripotent stem cells derived cardiomyocytes
by: Lopez, C
Published: (2018)

Machine-learning prediction of hosts of novel coronaviruses requires caution as it may affect wildlife conservation
by: Rasmussen, SL, et al.
Published: (2022)

Penehcyclidine and awareness during anaesthesia: caution with zero numerators.
by: Pandit, J, et al.
Published: (2013)

Penehcyclidine and awareness during anaesthesia: Caution with zero numerators
by: Pandit, J, et al.
Published: (2013)

Electroretinogram (ERG) recordings in mice lacking melanopsin.
by: Barnard, A, et al.
Published: (2004)

Adipose Tissue-derived Stem Cells Differentiated into Cardiomyocytes in Cardiac Microenvironment
by: Yan-Xia, Z, et al.
Published: (2009)

Atrial cardiomyocytes development from human induced pluripotent stem cells
by: Yuan, M
Published: (2018)

Contributions of HERG K+ current to repolarization of the human ventricular action potential.
by: Fink, M, et al.
Published: (2008)

HIV-1 superinfection--a word of caution.
by: Goulder, P, et al.
Published: (2002)

Molecular Mechanisms Of Mitragynine Inhibition On Herg1a/1b Channel
by: Tay, Yea Lu
Published: (2018)

Intranasal midazolam for treating febrile seizures in children. Caution is required in applying hospital based evidence to primary care population.
by: Harnden, A
Published: (2001)

Exercise caution on the roads even with less traffic during aidilfitri - road safety advocate
by: New Sabah Times
Published: (2020)

Reporting on suicidal behaviour and COVID-19—need for caution
by: Hawton, K, et al.
Published: (2020)

Trade marks and freedom of expression - A call for caution
by: Burrell, R, et al.
Published: (2010)

Extrapolating demography with climate, proximity and phylogeny: approach with caution
by: Coutts, SR, et al.
Published: (2016)

Use caution when applying behavioural science to policy
by: IJzerman, H, et al.
Published: (2020)

Height, Obesity, and the Risk of TMPRSS2:ERG-Defined Prostate Cancer
by: Graff, Rebecca E., et al.
Published: (2022)

Height, obesity, and the risk of TMPRSS2:ERG -defined prostate cancer
by: Graff, Rebecca E, et al.
Published: (2021)

Potential differentiation of human amniotic epithelial stem and mesenchymal bone marrow cells into cardiomyocytes
by: Motamedi, Batool
Published: (2015)