A mass action model of a fibroblast growth factor signaling pathway and its simplification
We consider a kinetic law of mass action model for Fibroblast Growth Factor (FGF) signaling, focusing on the induction of the RAS-MAP kinase pathway via GRB2 binding. Our biologically simple model suffers a combinatorial explosion in the number of differential equations required to simulate the syst...
Main Authors: | Gaffney, E, Heath, J, Kwiatkowska, M |
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格式: | Journal article |
出版: |
Springer
2008
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