A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates.

Isolated populations can empower the identification of rare variation associated with complex traits through next generation association studies, but the generalizability of such findings remains unknown. Here we genotype 1,267 individuals from a Greek population isolate on the Illumina HumanExome B...

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Hlavní autoři:	Tachmazidou, I, Dedoussis, G, Southam, L, Farmaki, A, Ritchie, G, Xifara, D, Matchan, A, Hatzikotoulas, K, Rayner, N, Chen, Y, Pollin, T, O'Connell, JR, Yerges-Armstrong, L, Kiagiadaki, C, Panoutsopoulou, K, Schwartzentruber, J, Moutsianas, L, Tsafantakis, E, Tyler-Smith, C, McVean, G, Xue, Y, Zeggini, E
Médium:	Journal article
Jazyk:	English
Vydáno:	Nature Publishing Group 2013

A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates.

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