Risk factors for influenza-related complications in children during the 2009/10 pandemic: a UK primary care cohort study using linked routinely collected data
<p>Primary care clinicians have a central role in managing influenza/influenza-like illness (ILI) during influenza pandemics. This study identifies risk factors for influenza-related complications in children presenting with influenza/ILI in primary care. We conducted a cohort study using rou...
| Main Authors: | , , , , , |
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| Format: | Journal article |
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Cambridge University Press
2018
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| _version_ | 1797074815428853760 |
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| author | Lee, J Bankhead, C Smith, M Kousoulis, A Butler, C Wang, K |
| author_facet | Lee, J Bankhead, C Smith, M Kousoulis, A Butler, C Wang, K |
| author_sort | Lee, J |
| collection | OXFORD |
| description | <p>Primary care clinicians have a central role in managing influenza/influenza-like illness (ILI) during influenza pandemics. This study identifies risk factors for influenza-related complications in children presenting with influenza/ILI in primary care. We conducted a cohort study using routinely collected linked data from the Clinical Practice Research Datalink on children aged 17 years and younger who presented with influenza/ILI during the 2009/10 pandemic. We calculated odds ratios for potential risk factors in relation to influenza-related complications, complications requiring intervention, pneumonia, all-cause hospitalisation, and hospitalisation due to influenza-related complications within 30 days of presentation. Analyses were adjusted for potential confounders including age, vaccination, and socioeconomic deprivation. Asthma was a risk factor for influenza-related complications (adjusted odds ratio [OR] 1.48, 95% confidence interval (CI) 1.21-1.80, P<0.001), complications requiring intervention (adjusted OR 1.44, 95% CI 1.11-1.88; P=0.007), pneumonia (adjusted OR 1.64, 95% CI 1.07-2.51, P=0.024), and hospitalisation due to influenza-related complications (adjusted OR 2.46, 95% CI 1.09-5.56, P=0.031). Neurological conditions were risk factors for all-cause hospitalisation (adjusted OR 4.25, 95% CI 1.50-12.07, P=0.007) but not influenza-related complications (adjusted OR 1.46, 95% CI 0.83-2.56, P=0.189). Community-based early interventions to prevent influenza-related clinical deterioration should therefore be primarily targeted at children with asthma and neurological conditions.</p> |
| first_indexed | 2024-03-06T23:41:40Z |
| format | Journal article |
| id | oxford-uuid:6f8afc3e-0afa-4670-ad6c-79b7f7203dcf |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:41:40Z |
| publishDate | 2018 |
| publisher | Cambridge University Press |
| record_format | dspace |
| spelling | oxford-uuid:6f8afc3e-0afa-4670-ad6c-79b7f7203dcf2022-03-26T19:31:16ZRisk factors for influenza-related complications in children during the 2009/10 pandemic: a UK primary care cohort study using linked routinely collected dataJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6f8afc3e-0afa-4670-ad6c-79b7f7203dcfSymplectic Elements at OxfordCambridge University Press2018Lee, JBankhead, CSmith, MKousoulis, AButler, CWang, K<p>Primary care clinicians have a central role in managing influenza/influenza-like illness (ILI) during influenza pandemics. This study identifies risk factors for influenza-related complications in children presenting with influenza/ILI in primary care. We conducted a cohort study using routinely collected linked data from the Clinical Practice Research Datalink on children aged 17 years and younger who presented with influenza/ILI during the 2009/10 pandemic. We calculated odds ratios for potential risk factors in relation to influenza-related complications, complications requiring intervention, pneumonia, all-cause hospitalisation, and hospitalisation due to influenza-related complications within 30 days of presentation. Analyses were adjusted for potential confounders including age, vaccination, and socioeconomic deprivation. Asthma was a risk factor for influenza-related complications (adjusted odds ratio [OR] 1.48, 95% confidence interval (CI) 1.21-1.80, P<0.001), complications requiring intervention (adjusted OR 1.44, 95% CI 1.11-1.88; P=0.007), pneumonia (adjusted OR 1.64, 95% CI 1.07-2.51, P=0.024), and hospitalisation due to influenza-related complications (adjusted OR 2.46, 95% CI 1.09-5.56, P=0.031). Neurological conditions were risk factors for all-cause hospitalisation (adjusted OR 4.25, 95% CI 1.50-12.07, P=0.007) but not influenza-related complications (adjusted OR 1.46, 95% CI 0.83-2.56, P=0.189). Community-based early interventions to prevent influenza-related clinical deterioration should therefore be primarily targeted at children with asthma and neurological conditions.</p> |
| spellingShingle | Lee, J Bankhead, C Smith, M Kousoulis, A Butler, C Wang, K Risk factors for influenza-related complications in children during the 2009/10 pandemic: a UK primary care cohort study using linked routinely collected data |
| title | Risk factors for influenza-related complications in children during the 2009/10 pandemic: a UK primary care cohort study using linked routinely collected data |
| title_full | Risk factors for influenza-related complications in children during the 2009/10 pandemic: a UK primary care cohort study using linked routinely collected data |
| title_fullStr | Risk factors for influenza-related complications in children during the 2009/10 pandemic: a UK primary care cohort study using linked routinely collected data |
| title_full_unstemmed | Risk factors for influenza-related complications in children during the 2009/10 pandemic: a UK primary care cohort study using linked routinely collected data |
| title_short | Risk factors for influenza-related complications in children during the 2009/10 pandemic: a UK primary care cohort study using linked routinely collected data |
| title_sort | risk factors for influenza related complications in children during the 2009 10 pandemic a uk primary care cohort study using linked routinely collected data |
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