Normal circulating immunoreactive growth hormone releasing factor (hGRF) concentrations in patients with functional hypothalamic hGRF deficiency.
Using a highly specific radioimmunoassay we have measured the concentrations of human growth hormone releasing factor (ir-hGRF) in the peripheral circulation of six individuals with acquired hypothalamic hGRF deficiency. Despite their hypothalamic dysfunction venous plasma ir-hGRF increased normally...
| Những tác giả chính: | , , , , , |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
1986
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| _version_ | 1826278291694157824 |
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| author | Sopwith, A Penny, E Grossman, A Savage, M Besser, G Rees, L |
| author_facet | Sopwith, A Penny, E Grossman, A Savage, M Besser, G Rees, L |
| author_sort | Sopwith, A |
| collection | OXFORD |
| description | Using a highly specific radioimmunoassay we have measured the concentrations of human growth hormone releasing factor (ir-hGRF) in the peripheral circulation of six individuals with acquired hypothalamic hGRF deficiency. Despite their hypothalamic dysfunction venous plasma ir-hGRF increased normally in every patient after the stimulus of a mixed breakfast, from an average concentration basally of 13.6 +/- 6.0 pg/ml to a maximum of 29.0 +/- 8.4 pg/ml (mean +/- SEM) at 120 min. The findings indicate that circulating hGRF is at least in large part extrahypothalamic in origin, which in turn implies a physiological role for hGRF in the periphery. |
| first_indexed | 2024-03-06T23:41:45Z |
| format | Journal article |
| id | oxford-uuid:6f925373-3897-4a48-a6cf-3deb0eb9fc38 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:41:45Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:6f925373-3897-4a48-a6cf-3deb0eb9fc382022-03-26T19:31:23ZNormal circulating immunoreactive growth hormone releasing factor (hGRF) concentrations in patients with functional hypothalamic hGRF deficiency.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6f925373-3897-4a48-a6cf-3deb0eb9fc38EnglishSymplectic Elements at Oxford1986Sopwith, APenny, EGrossman, ASavage, MBesser, GRees, LUsing a highly specific radioimmunoassay we have measured the concentrations of human growth hormone releasing factor (ir-hGRF) in the peripheral circulation of six individuals with acquired hypothalamic hGRF deficiency. Despite their hypothalamic dysfunction venous plasma ir-hGRF increased normally in every patient after the stimulus of a mixed breakfast, from an average concentration basally of 13.6 +/- 6.0 pg/ml to a maximum of 29.0 +/- 8.4 pg/ml (mean +/- SEM) at 120 min. The findings indicate that circulating hGRF is at least in large part extrahypothalamic in origin, which in turn implies a physiological role for hGRF in the periphery. |
| spellingShingle | Sopwith, A Penny, E Grossman, A Savage, M Besser, G Rees, L Normal circulating immunoreactive growth hormone releasing factor (hGRF) concentrations in patients with functional hypothalamic hGRF deficiency. |
| title | Normal circulating immunoreactive growth hormone releasing factor (hGRF) concentrations in patients with functional hypothalamic hGRF deficiency. |
| title_full | Normal circulating immunoreactive growth hormone releasing factor (hGRF) concentrations in patients with functional hypothalamic hGRF deficiency. |
| title_fullStr | Normal circulating immunoreactive growth hormone releasing factor (hGRF) concentrations in patients with functional hypothalamic hGRF deficiency. |
| title_full_unstemmed | Normal circulating immunoreactive growth hormone releasing factor (hGRF) concentrations in patients with functional hypothalamic hGRF deficiency. |
| title_short | Normal circulating immunoreactive growth hormone releasing factor (hGRF) concentrations in patients with functional hypothalamic hGRF deficiency. |
| title_sort | normal circulating immunoreactive growth hormone releasing factor hgrf concentrations in patients with functional hypothalamic hgrf deficiency |
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