A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects.
BACKGROUND: High-fat, low-carbohydrate diets are widely used for weight reduction, but they may also have detrimental effects via increased circulating free fatty acid concentrations. OBJECTIVE: We tested whether raising plasma free fatty acids by using a high-fat, low-carbohydrate diet results in a...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2011
|
| _version_ | 1797074824600748032 |
|---|---|
| author | Holloway, C Cochlin, L Emmanuel, Y Murray, A Codreanu, I Edwards, L Szmigielski, C Tyler, D Knight, N Saxby, B Lambert, B Thompson, C Neubauer, S Clarke, K |
| author_facet | Holloway, C Cochlin, L Emmanuel, Y Murray, A Codreanu, I Edwards, L Szmigielski, C Tyler, D Knight, N Saxby, B Lambert, B Thompson, C Neubauer, S Clarke, K |
| author_sort | Holloway, C |
| collection | OXFORD |
| description | BACKGROUND: High-fat, low-carbohydrate diets are widely used for weight reduction, but they may also have detrimental effects via increased circulating free fatty acid concentrations. OBJECTIVE: We tested whether raising plasma free fatty acids by using a high-fat, low-carbohydrate diet results in alterations in heart and brain in healthy subjects. DESIGN: Men (n = 16) aged 22 ± 1 y (mean ± SE) were randomly assigned to 5 d of a high-fat, low-carbohydrate diet containing 75 ± 1% of calorie intake through fat consumption or to an isocaloric standard diet providing 23 ± 1% of calorie intake as fat. In a crossover design, subjects undertook the alternate diet after a 2-wk washout period, with results compared after the diet periods. Cardiac (31)P magnetic resonance (MR) spectroscopy and MR imaging, echocardiography, and computerized cognitive tests were used to assess cardiac phosphocreatine (PCr)/ATP, cardiac function, and cognitive function, respectively. RESULTS: Compared with the standard diet, subjects who consumed the high-fat, low-carbohydrate diet had 44% higher plasma free fatty acids (P < 0.05), 9% lower cardiac PCr/ATP (P < 0.01), and no change in cardiac function. Cognitive tests showed impaired attention (P < 0.01), speed (P < 0.001), and mood (P < 0.01) after the high-fat, low-carbohydrate diet. CONCLUSION: Raising plasma free fatty acids decreased myocardial PCr/ATP and reduced cognition, which suggests that a high-fat diet is detrimental to heart and brain in healthy subjects. |
| first_indexed | 2024-03-06T23:41:48Z |
| format | Journal article |
| id | oxford-uuid:6f95df1c-1706-44e7-94be-10eb2409d064 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:41:48Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:6f95df1c-1706-44e7-94be-10eb2409d0642022-03-26T19:31:32ZA high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6f95df1c-1706-44e7-94be-10eb2409d064EnglishSymplectic Elements at Oxford2011Holloway, CCochlin, LEmmanuel, YMurray, ACodreanu, IEdwards, LSzmigielski, CTyler, DKnight, NSaxby, BLambert, BThompson, CNeubauer, SClarke, KBACKGROUND: High-fat, low-carbohydrate diets are widely used for weight reduction, but they may also have detrimental effects via increased circulating free fatty acid concentrations. OBJECTIVE: We tested whether raising plasma free fatty acids by using a high-fat, low-carbohydrate diet results in alterations in heart and brain in healthy subjects. DESIGN: Men (n = 16) aged 22 ± 1 y (mean ± SE) were randomly assigned to 5 d of a high-fat, low-carbohydrate diet containing 75 ± 1% of calorie intake through fat consumption or to an isocaloric standard diet providing 23 ± 1% of calorie intake as fat. In a crossover design, subjects undertook the alternate diet after a 2-wk washout period, with results compared after the diet periods. Cardiac (31)P magnetic resonance (MR) spectroscopy and MR imaging, echocardiography, and computerized cognitive tests were used to assess cardiac phosphocreatine (PCr)/ATP, cardiac function, and cognitive function, respectively. RESULTS: Compared with the standard diet, subjects who consumed the high-fat, low-carbohydrate diet had 44% higher plasma free fatty acids (P < 0.05), 9% lower cardiac PCr/ATP (P < 0.01), and no change in cardiac function. Cognitive tests showed impaired attention (P < 0.01), speed (P < 0.001), and mood (P < 0.01) after the high-fat, low-carbohydrate diet. CONCLUSION: Raising plasma free fatty acids decreased myocardial PCr/ATP and reduced cognition, which suggests that a high-fat diet is detrimental to heart and brain in healthy subjects. |
| spellingShingle | Holloway, C Cochlin, L Emmanuel, Y Murray, A Codreanu, I Edwards, L Szmigielski, C Tyler, D Knight, N Saxby, B Lambert, B Thompson, C Neubauer, S Clarke, K A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects. |
| title | A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects. |
| title_full | A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects. |
| title_fullStr | A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects. |
| title_full_unstemmed | A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects. |
| title_short | A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects. |
| title_sort | high fat diet impairs cardiac high energy phosphate metabolism and cognitive function in healthy human subjects |
| work_keys_str_mv | AT hollowayc ahighfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT cochlinl ahighfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT emmanuely ahighfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT murraya ahighfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT codreanui ahighfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT edwardsl ahighfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT szmigielskic ahighfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT tylerd ahighfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT knightn ahighfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT saxbyb ahighfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT lambertb ahighfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT thompsonc ahighfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT neubauers ahighfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT clarkek ahighfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT hollowayc highfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT cochlinl highfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT emmanuely highfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT murraya highfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT codreanui highfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT edwardsl highfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT szmigielskic highfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT tylerd highfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT knightn highfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT saxbyb highfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT lambertb highfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT thompsonc highfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT neubauers highfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects AT clarkek highfatdietimpairscardiachighenergyphosphatemetabolismandcognitivefunctioninhealthyhumansubjects |