ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma
Anterior chamber depth (ACD) is a key anatomical risk factor for primary angle closure glaucoma (PACG). We conducted a genome-wide association study (GWAS) on ACD to discover novel genes for PACG on a total of 5,308 population-based individuals of Asian descent. Genome-wide significant association w...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| 格式: | Journal article |
| 语言: | English |
| 出版: |
Public Library of Science
2014
|
| _version_ | 1826278315683479552 |
|---|---|
| author | Nongpiur, M Khor, C Jia, H Cornes, B Chen, L Qiao, C Nair, K Cheng, C Xu, L George, R Tan, D Abu-Amero, K Perera, S Ozaki, M Mizoguchi, T Kurimoto, Y Low, S Tajudin, L Ho, C Tham, C Soto, I Chew, P Wong, H Shantha, B Kuroda, M Osman, E Tang, G Fan, S Meng, H Wang, H Feng, B Yong, V Ting, S Li, Y Wang, Y Li, Z Lavanya, R Wu, R Zheng, Y Su, D Loon, S Yong, V Allingham, R Hauser, M Soumittra, N Ramprasad, V Waseem, N Yaakub, A Chia, K Kumaramanickavel, G Wong, T How, A Chau, T Simmons, C Bei, J Zeng, Y Bhattacharya, S Zhang, M Tan, D Teo, Y Al-Obeidan, S Hon, D Tai, E Saw, S Foster, P Vijaya, L Jonas, J Wong, T John, S Pang, C Vithana, E Wang, N Aung, T |
| author_facet | Nongpiur, M Khor, C Jia, H Cornes, B Chen, L Qiao, C Nair, K Cheng, C Xu, L George, R Tan, D Abu-Amero, K Perera, S Ozaki, M Mizoguchi, T Kurimoto, Y Low, S Tajudin, L Ho, C Tham, C Soto, I Chew, P Wong, H Shantha, B Kuroda, M Osman, E Tang, G Fan, S Meng, H Wang, H Feng, B Yong, V Ting, S Li, Y Wang, Y Li, Z Lavanya, R Wu, R Zheng, Y Su, D Loon, S Yong, V Allingham, R Hauser, M Soumittra, N Ramprasad, V Waseem, N Yaakub, A Chia, K Kumaramanickavel, G Wong, T How, A Chau, T Simmons, C Bei, J Zeng, Y Bhattacharya, S Zhang, M Tan, D Teo, Y Al-Obeidan, S Hon, D Tai, E Saw, S Foster, P Vijaya, L Jonas, J Wong, T John, S Pang, C Vithana, E Wang, N Aung, T |
| author_sort | Nongpiur, M |
| collection | OXFORD |
| description | Anterior chamber depth (ACD) is a key anatomical risk factor for primary angle closure glaucoma (PACG). We conducted a genome-wide association study (GWAS) on ACD to discover novel genes for PACG on a total of 5,308 population-based individuals of Asian descent. Genome-wide significant association was observed at a sequence variant within ABCC5 (rs1401999; per-allele effect size = -0.045 mm, P = 8.17 × 10(-9)). This locus was associated with an increase in risk of PACG in a separate case-control study of 4,276 PACG cases and 18,801 controls (per-allele OR = 1.13 [95% CI: 1.06-1.22], P = 0.00046). The association was strengthened when a sub-group of controls with open angles were included in the analysis (per-allele OR = 1.30, P = 7.45 × 10(-9); 3,458 cases vs. 3,831 controls). Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants influencing anterior chamber dimensions. |
| first_indexed | 2024-03-06T23:42:06Z |
| format | Journal article |
| id | oxford-uuid:6facdebc-4c5e-4a75-ad14-fdb2f0f66aa5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:42:06Z |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:6facdebc-4c5e-4a75-ad14-fdb2f0f66aa52022-03-26T19:32:17ZABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucomaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6facdebc-4c5e-4a75-ad14-fdb2f0f66aa5EnglishSymplectic Elements at OxfordPublic Library of Science2014Nongpiur, MKhor, CJia, HCornes, BChen, LQiao, CNair, KCheng, CXu, LGeorge, RTan, DAbu-Amero, KPerera, SOzaki, MMizoguchi, TKurimoto, YLow, STajudin, LHo, CTham, CSoto, IChew, PWong, HShantha, BKuroda, MOsman, ETang, GFan, SMeng, HWang, HFeng, BYong, VTing, SLi, YWang, YLi, ZLavanya, RWu, RZheng, YSu, DLoon, SYong, VAllingham, RHauser, MSoumittra, NRamprasad, VWaseem, NYaakub, AChia, KKumaramanickavel, GWong, THow, AChau, TSimmons, CBei, JZeng, YBhattacharya, SZhang, MTan, DTeo, YAl-Obeidan, SHon, DTai, ESaw, SFoster, PVijaya, LJonas, JWong, TJohn, SPang, CVithana, EWang, NAung, TAnterior chamber depth (ACD) is a key anatomical risk factor for primary angle closure glaucoma (PACG). We conducted a genome-wide association study (GWAS) on ACD to discover novel genes for PACG on a total of 5,308 population-based individuals of Asian descent. Genome-wide significant association was observed at a sequence variant within ABCC5 (rs1401999; per-allele effect size = -0.045 mm, P = 8.17 × 10(-9)). This locus was associated with an increase in risk of PACG in a separate case-control study of 4,276 PACG cases and 18,801 controls (per-allele OR = 1.13 [95% CI: 1.06-1.22], P = 0.00046). The association was strengthened when a sub-group of controls with open angles were included in the analysis (per-allele OR = 1.30, P = 7.45 × 10(-9); 3,458 cases vs. 3,831 controls). Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants influencing anterior chamber dimensions. |
| spellingShingle | Nongpiur, M Khor, C Jia, H Cornes, B Chen, L Qiao, C Nair, K Cheng, C Xu, L George, R Tan, D Abu-Amero, K Perera, S Ozaki, M Mizoguchi, T Kurimoto, Y Low, S Tajudin, L Ho, C Tham, C Soto, I Chew, P Wong, H Shantha, B Kuroda, M Osman, E Tang, G Fan, S Meng, H Wang, H Feng, B Yong, V Ting, S Li, Y Wang, Y Li, Z Lavanya, R Wu, R Zheng, Y Su, D Loon, S Yong, V Allingham, R Hauser, M Soumittra, N Ramprasad, V Waseem, N Yaakub, A Chia, K Kumaramanickavel, G Wong, T How, A Chau, T Simmons, C Bei, J Zeng, Y Bhattacharya, S Zhang, M Tan, D Teo, Y Al-Obeidan, S Hon, D Tai, E Saw, S Foster, P Vijaya, L Jonas, J Wong, T John, S Pang, C Vithana, E Wang, N Aung, T ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma |
| title | ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma |
| title_full | ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma |
| title_fullStr | ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma |
| title_full_unstemmed | ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma |
| title_short | ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma |
| title_sort | abcc5 a gene that influences the anterior chamber depth is associated with primary angle closure glaucoma |
| work_keys_str_mv | AT nongpiurm abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT khorc abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT jiah abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT cornesb abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT chenl abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT qiaoc abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT nairk abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT chengc abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT xul abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT georger abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT tand abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT abuamerok abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT pereras abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT ozakim abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT mizoguchit abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT kurimotoy abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT lows abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT tajudinl abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT hoc abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT thamc abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT sotoi abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT chewp abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT wongh abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT shanthab abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT kurodam abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT osmane abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT tangg abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT fans abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT mengh abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT wangh abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT fengb abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT yongv abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT tings abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT liy abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT wangy abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT liz abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT lavanyar abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT wur abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT zhengy abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT sud abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT loons abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT yongv abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT allinghamr abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT hauserm abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT soumittran abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT ramprasadv abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT waseemn abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT yaakuba abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT chiak abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT kumaramanickavelg abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT wongt abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT howa abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT chaut abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT simmonsc abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT beij abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT zengy abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT bhattacharyas abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT zhangm abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT tand abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT teoy abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT alobeidans abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT hond abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT taie abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT saws abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT fosterp abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT vijayal abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT jonasj abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT wongt abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT johns abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT pangc abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT vithanae abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT wangn abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma AT aungt abcc5agenethatinfluencestheanteriorchamberdepthisassociatedwithprimaryangleclosureglaucoma |