Asymmetric synthesis of (R)-hexane-1,5-diol and (R)-hex-3-ene-1,5-diol via a tandem asymmetric conjugate addition stereospecific Meisenheimer rearrangement protocol
Stereoselective conjugate addition of (R)-lithium N,α-dimethylbenzylamide to tert-butyl (E,E)-hexa-2,4-dienoate, followed by reduction of the ester to the corresponding alcohol, affords a substrate which undergoes, on oxidation, a stereospecific Meisenheimer rearrangement to give a single diastereom...
| Main Authors: | , |
|---|---|
| 格式: | Journal article |
| 語言: | English |
| 出版: |
1996
|