The role of T cell receptor dimerization for T cell antagonism and T cell specificity.
T cell responses are highly specific and T cell receptors (TCRs) can recognise subtle differences in major histocompatibility complex (MHC)-peptide complexes. While nominal peptide antigens usually act as full agonists that trigger the whole spectrum of T cell responses, some peptides exhibiting mut...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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1998
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| _version_ | 1797074863918153728 |
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| author | Salzmann, M Bachmann, M |
| author_facet | Salzmann, M Bachmann, M |
| author_sort | Salzmann, M |
| collection | OXFORD |
| description | T cell responses are highly specific and T cell receptors (TCRs) can recognise subtle differences in major histocompatibility complex (MHC)-peptide complexes. While nominal peptide antigens usually act as full agonists that trigger the whole spectrum of T cell responses, some peptides exhibiting mutations at the TCR-MHC/peptide contact site stimulate only a fraction of T cell responses (partial agonists) or may even inhibit T cell activation by full agonists (antagonist). The present study analyses mathematically the role of TCR-dimerization for T cell antagonism and T cell specificity in general. It demonstrates that T cell antagonists can effectively inhibit TCR-dimerization and that this mechanism can sufficiently explain all aspects of T cell antagonism. The kinetic model of T cell activation proposes that increasing the time required for effective TCR-signaling is the most effective mechanism to increase the discriminatory capacity of TCRs. Our results indicate that TCR-oligomerization is an alternative and efficient mechanism to ensure T cell specificity. |
| first_indexed | 2024-03-06T23:42:23Z |
| format | Journal article |
| id | oxford-uuid:6fc3f762-8b58-41de-95c9-7d5d169adf95 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:42:23Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:6fc3f762-8b58-41de-95c9-7d5d169adf952022-03-26T19:32:42ZThe role of T cell receptor dimerization for T cell antagonism and T cell specificity.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6fc3f762-8b58-41de-95c9-7d5d169adf95EnglishSymplectic Elements at Oxford1998Salzmann, MBachmann, MT cell responses are highly specific and T cell receptors (TCRs) can recognise subtle differences in major histocompatibility complex (MHC)-peptide complexes. While nominal peptide antigens usually act as full agonists that trigger the whole spectrum of T cell responses, some peptides exhibiting mutations at the TCR-MHC/peptide contact site stimulate only a fraction of T cell responses (partial agonists) or may even inhibit T cell activation by full agonists (antagonist). The present study analyses mathematically the role of TCR-dimerization for T cell antagonism and T cell specificity in general. It demonstrates that T cell antagonists can effectively inhibit TCR-dimerization and that this mechanism can sufficiently explain all aspects of T cell antagonism. The kinetic model of T cell activation proposes that increasing the time required for effective TCR-signaling is the most effective mechanism to increase the discriminatory capacity of TCRs. Our results indicate that TCR-oligomerization is an alternative and efficient mechanism to ensure T cell specificity. |
| spellingShingle | Salzmann, M Bachmann, M The role of T cell receptor dimerization for T cell antagonism and T cell specificity. |
| title | The role of T cell receptor dimerization for T cell antagonism and T cell specificity. |
| title_full | The role of T cell receptor dimerization for T cell antagonism and T cell specificity. |
| title_fullStr | The role of T cell receptor dimerization for T cell antagonism and T cell specificity. |
| title_full_unstemmed | The role of T cell receptor dimerization for T cell antagonism and T cell specificity. |
| title_short | The role of T cell receptor dimerization for T cell antagonism and T cell specificity. |
| title_sort | role of t cell receptor dimerization for t cell antagonism and t cell specificity |
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