Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1.
Glucagon-like peptide 1 is a gastrointestinally derived hormone with profound effects on nutrient-induced pancreatic hormone release. GLP-1 modulates insulin, glucagon and somatostatin secretion by binding to guanine nucleotide binding protein-coupled receptors resulting in the activation of adenyla...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1998
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| _version_ | 1797074872834195456 |
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| author | Gromada, J Holst, J Rorsman, P |
| author_facet | Gromada, J Holst, J Rorsman, P |
| author_sort | Gromada, J |
| collection | OXFORD |
| description | Glucagon-like peptide 1 is a gastrointestinally derived hormone with profound effects on nutrient-induced pancreatic hormone release. GLP-1 modulates insulin, glucagon and somatostatin secretion by binding to guanine nucleotide binding protein-coupled receptors resulting in the activation of adenylate cyclase and generation of cyclic adenosine monophosphate (cAMP). In the B-cell, cAMP, via activation of protein kinase A, interacts with a plethora of signal transduction processes including ion channel activity, intracellular Ca2+ handling and exocytosis of the insulin-containing granules. The stimulatory action of GLP-1 on insulin secretion, contrary to that of the currently used hypoglycaemic sulphonylureas, is glucose dependent and requires the presence of normal or elevated concentrations of the sugar. For this reason, GLP-1 attracts much interest as a possible novel principle for the treatment of human type-2 diabetes. Here we review the actions of GLP-1 on islet cell function and attempt to integrate current knowledge into a working model for the control of pancreatic hormone secretion. |
| first_indexed | 2024-03-06T23:42:31Z |
| format | Journal article |
| id | oxford-uuid:6fcf20f7-72e1-4c85-a42d-26f8c650f525 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:42:31Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:6fcf20f7-72e1-4c85-a42d-26f8c650f5252022-03-26T19:33:02ZCellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6fcf20f7-72e1-4c85-a42d-26f8c650f525EnglishSymplectic Elements at Oxford1998Gromada, JHolst, JRorsman, PGlucagon-like peptide 1 is a gastrointestinally derived hormone with profound effects on nutrient-induced pancreatic hormone release. GLP-1 modulates insulin, glucagon and somatostatin secretion by binding to guanine nucleotide binding protein-coupled receptors resulting in the activation of adenylate cyclase and generation of cyclic adenosine monophosphate (cAMP). In the B-cell, cAMP, via activation of protein kinase A, interacts with a plethora of signal transduction processes including ion channel activity, intracellular Ca2+ handling and exocytosis of the insulin-containing granules. The stimulatory action of GLP-1 on insulin secretion, contrary to that of the currently used hypoglycaemic sulphonylureas, is glucose dependent and requires the presence of normal or elevated concentrations of the sugar. For this reason, GLP-1 attracts much interest as a possible novel principle for the treatment of human type-2 diabetes. Here we review the actions of GLP-1 on islet cell function and attempt to integrate current knowledge into a working model for the control of pancreatic hormone secretion. |
| spellingShingle | Gromada, J Holst, J Rorsman, P Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1. |
| title | Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1. |
| title_full | Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1. |
| title_fullStr | Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1. |
| title_full_unstemmed | Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1. |
| title_short | Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1. |
| title_sort | cellular regulation of islet hormone secretion by the incretin hormone glucagon like peptide 1 |
| work_keys_str_mv | AT gromadaj cellularregulationofislethormonesecretionbytheincretinhormoneglucagonlikepeptide1 AT holstj cellularregulationofislethormonesecretionbytheincretinhormoneglucagonlikepeptide1 AT rorsmanp cellularregulationofislethormonesecretionbytheincretinhormoneglucagonlikepeptide1 |