Interval timing in mice does not rely upon the circadian pacemaker.
The suprachiasmatic nucleus (SCN) of the hypothalamus is a precise timekeeper that controls and synchronizes the circadian period of countless physiological and behavioural functions and entrains them to the 24 h light/dark cycle. We examined the possibility that it is also indirectly involved in me...
| Hlavní autoři: | , , , |
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
2003
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| _version_ | 1826278345373908992 |
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| author | Lewis, P Miall, R Daan, S Kacelnik, A |
| author_facet | Lewis, P Miall, R Daan, S Kacelnik, A |
| author_sort | Lewis, P |
| collection | OXFORD |
| description | The suprachiasmatic nucleus (SCN) of the hypothalamus is a precise timekeeper that controls and synchronizes the circadian period of countless physiological and behavioural functions and entrains them to the 24 h light/dark cycle. We examined the possibility that it is also indirectly involved in measurement of a briefer interval by observing the effects of lesions targeted at the SCN, and abolishing circadian rhythmicity, upon interval timing behaviour. Fourteen house mice (Mus musculus) were trained to estimate a 10 s interval using a modified peak procedure, and then underwent electrolytic lesions. Six individuals became behaviourally arrhythmic. Peak interval performance was then assessed in 12:12 light/dark conditions and in constant darkness. No significant change in peak characteristics was observed as a consequence of the lesion for either rhythmic or arrhythmic groups. These results show that the accurate measurement of 10 s requires neither a functioning circadian pacemaker nor entrained behavioural rhythmicity. |
| first_indexed | 2024-03-06T23:42:32Z |
| format | Journal article |
| id | oxford-uuid:6fd0d714-6724-467f-98dc-355b6006fb88 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:42:32Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:6fd0d714-6724-467f-98dc-355b6006fb882022-03-26T19:33:03ZInterval timing in mice does not rely upon the circadian pacemaker.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6fd0d714-6724-467f-98dc-355b6006fb88EnglishSymplectic Elements at Oxford2003Lewis, PMiall, RDaan, SKacelnik, AThe suprachiasmatic nucleus (SCN) of the hypothalamus is a precise timekeeper that controls and synchronizes the circadian period of countless physiological and behavioural functions and entrains them to the 24 h light/dark cycle. We examined the possibility that it is also indirectly involved in measurement of a briefer interval by observing the effects of lesions targeted at the SCN, and abolishing circadian rhythmicity, upon interval timing behaviour. Fourteen house mice (Mus musculus) were trained to estimate a 10 s interval using a modified peak procedure, and then underwent electrolytic lesions. Six individuals became behaviourally arrhythmic. Peak interval performance was then assessed in 12:12 light/dark conditions and in constant darkness. No significant change in peak characteristics was observed as a consequence of the lesion for either rhythmic or arrhythmic groups. These results show that the accurate measurement of 10 s requires neither a functioning circadian pacemaker nor entrained behavioural rhythmicity. |
| spellingShingle | Lewis, P Miall, R Daan, S Kacelnik, A Interval timing in mice does not rely upon the circadian pacemaker. |
| title | Interval timing in mice does not rely upon the circadian pacemaker. |
| title_full | Interval timing in mice does not rely upon the circadian pacemaker. |
| title_fullStr | Interval timing in mice does not rely upon the circadian pacemaker. |
| title_full_unstemmed | Interval timing in mice does not rely upon the circadian pacemaker. |
| title_short | Interval timing in mice does not rely upon the circadian pacemaker. |
| title_sort | interval timing in mice does not rely upon the circadian pacemaker |
| work_keys_str_mv | AT lewisp intervaltiminginmicedoesnotrelyuponthecircadianpacemaker AT miallr intervaltiminginmicedoesnotrelyuponthecircadianpacemaker AT daans intervaltiminginmicedoesnotrelyuponthecircadianpacemaker AT kacelnika intervaltiminginmicedoesnotrelyuponthecircadianpacemaker |