Chromatin and single-cell RNA-seq profiling reveal dynamic signaling and metabolic transitions during human spermatogonial stem cell development

Chromatin and single-cell RNA-seq profiling reveal dynamic signaling and metabolic transitions during human spermatogonial stem cell development

Human adult spermatogonial stem cells (hSSCs) must balance self-renewal and differentiation. To understand how this is achieved, we profiled DNA methylation and open chromatin (ATAC-seq) in SSEA4+ hSSCs, analyzed bulk and single-cell RNA transcriptomes (RNA-seq) in SSEA4+ hSSCs and differentiating c...

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Bibliographic Details
Main Authors:	Guo, J, Grow, E, Yi, C, Mlcochova, H, Maher, G, Lindskog, C, Murphy, P, Wike, C, Carrell, D, Goriely, A, Hotaling, J, Cairns, B
Format:	Journal article
Language:	English
Published:	Elsevier 2017

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