Modern solutions for ancient pathogens: direct pathogen sequencing for diagnosis of lepromatous leprosy and cerebral coenurosis
Microbes unculturable in vitro remain diagnostically challenging, dependent historically on clinical findings, histology, or targeted molecular detection. We applied whole-genome sequencing directly from tissue to diagnose infections with mycobacteria (leprosy) and parasites (coenurosis). Direct pat...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2022
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| _version_ | 1826309186383773696 |
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| author | Young, B Bush, S Lipworth, S George, S Dingle, K Sanderson, N brankin, A Walker, T Sharma, S Leong, J Plaha, P Hofer, M Chiodini, P Gottstein, B Furrer, L Crook, D Brent, A |
| author_facet | Young, B Bush, S Lipworth, S George, S Dingle, K Sanderson, N brankin, A Walker, T Sharma, S Leong, J Plaha, P Hofer, M Chiodini, P Gottstein, B Furrer, L Crook, D Brent, A |
| author_sort | Young, B |
| collection | OXFORD |
| description | Microbes unculturable in vitro remain diagnostically challenging, dependent historically on clinical findings, histology, or targeted molecular detection. We applied whole-genome sequencing directly from tissue to diagnose infections with mycobacteria (leprosy) and parasites (coenurosis). Direct pathogen DNA sequencing provides flexible solutions to diagnosis of difficult pathogens in diverse contexts. |
| first_indexed | 2024-03-07T07:30:23Z |
| format | Journal article |
| id | oxford-uuid:6fec9e62-b3d6-4f5c-9d20-7038bc05e449 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:30:23Z |
| publishDate | 2022 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:6fec9e62-b3d6-4f5c-9d20-7038bc05e4492023-01-16T11:15:07ZModern solutions for ancient pathogens: direct pathogen sequencing for diagnosis of lepromatous leprosy and cerebral coenurosis Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6fec9e62-b3d6-4f5c-9d20-7038bc05e449EnglishSymplectic ElementsOxford University Press2022Young, BBush, SLipworth, SGeorge, SDingle, KSanderson, Nbrankin, AWalker, TSharma, SLeong, JPlaha, PHofer, MChiodini, PGottstein, BFurrer, LCrook, DBrent, AMicrobes unculturable in vitro remain diagnostically challenging, dependent historically on clinical findings, histology, or targeted molecular detection. We applied whole-genome sequencing directly from tissue to diagnose infections with mycobacteria (leprosy) and parasites (coenurosis). Direct pathogen DNA sequencing provides flexible solutions to diagnosis of difficult pathogens in diverse contexts. |
| spellingShingle | Young, B Bush, S Lipworth, S George, S Dingle, K Sanderson, N brankin, A Walker, T Sharma, S Leong, J Plaha, P Hofer, M Chiodini, P Gottstein, B Furrer, L Crook, D Brent, A Modern solutions for ancient pathogens: direct pathogen sequencing for diagnosis of lepromatous leprosy and cerebral coenurosis |
| title | Modern solutions for ancient pathogens: direct pathogen sequencing for diagnosis of lepromatous leprosy and cerebral coenurosis |
| title_full | Modern solutions for ancient pathogens: direct pathogen sequencing for diagnosis of lepromatous leprosy and cerebral coenurosis |
| title_fullStr | Modern solutions for ancient pathogens: direct pathogen sequencing for diagnosis of lepromatous leprosy and cerebral coenurosis |
| title_full_unstemmed | Modern solutions for ancient pathogens: direct pathogen sequencing for diagnosis of lepromatous leprosy and cerebral coenurosis |
| title_short | Modern solutions for ancient pathogens: direct pathogen sequencing for diagnosis of lepromatous leprosy and cerebral coenurosis |
| title_sort | modern solutions for ancient pathogens direct pathogen sequencing for diagnosis of lepromatous leprosy and cerebral coenurosis |
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