Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.

Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.

BACKGROUND: Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (CTL)-mediated pressure and HIV-1 evolu...

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Bibliographic Details
Main Authors:	Rolland, M, Carlson, J, Manocheewa, S, Swain, J, Lanxon-Cookson, E, Deng, W, Rousseau, C, Raugi, D, Learn, G, Maust, B, Coovadia, H, Ndung'u, T, Goulder, P, Walker, B, Brander, C, Heckerman, D, Mullins, J
Format:	Journal article
Language:	English
Published:	2010

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