Beta-catenin mutations in cell lines established from human colorectal cancers.
beta-catenin has functions as both an adhesion and a signaling molecule. Disruption of these functions through mutations of the beta-catenin gene (CTNNB1) may be important in the development of colorectal tumors. We examined the entire coding sequence of beta-catenin by reverse transcriptase-PCR (RT...
Main Authors: | Ilyas, M, Tomlinson, I, Rowan, A, Pignatelli, M, Bodmer, W |
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Format: | Journal article |
Language: | English |
Published: |
1997
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