The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters.

The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters.

The transcription factor Runx1 plays a pivotal role in hematopoietic stem cell (HSC) emergence, and studies into its transcriptional regulation should give insight into the critical steps of HSC specification. Recently, we identified the Runx1 +23 enhancer that targets reporter gene expression to th...

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Bibliografiske detaljer
Main Authors:	Bee, T, Ashley, E, Bickley, SR, Jarratt, A, Li, P, Sloane-Stanley, J, Göttgens, B, de Bruijn, M
Format:	Journal article
Sprog:	English
Udgivet:	2009

Lignende værker

THE RUNX1+23 ENHANCER IS ACTIVE IN CELLS WITH BOTH ENDOTHELIAL AND HEMATOPOIETIC CHARACTERISTICS DURING MOUSE DEVELOPMENTAL HEMATOPOIESIS
af: Swiers, G, et al.
Udgivet: (2009)

Alternative Runx1 promoter usage in mouse developmental hematopoiesis.
af: Bee, T, et al.
Udgivet: (2009)

Hematopoietic stem cell emergence in the conceptus and the role of Runx1.
af: Swiers, G, et al.
Udgivet: (2010)

An intronic Runx1 enhancer directs transcription to the emerging hematopoietic system of the mouse embryo
af: Nottingham, W, et al.
Udgivet: (2007)

Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.
af: Nottingham, W, et al.
Udgivet: (2007)

Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells
af: Yoshiki Omatsu, et al.
Udgivet: (2022-05-01)

Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells.
af: North, T, et al.
Udgivet: (2004)

Runx1 loss minimally impacts long-term hematopoietic stem cells.
af: Xiongwei Cai, et al.
Udgivet: (2011-01-01)

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development
af: Owens, DDG, et al.
Udgivet: (2022)

Gata3 targets Runx1 in the embryonic haematopoietic stem cell niche
af: Fitch, SR, et al.
Udgivet: (2019)

A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis.
af: Knezevic, K, et al.
Udgivet: (2011)

CSF3R T618I Collaborates With RUNX1-RUNX1T1 to Expand Hematopoietic Progenitors and Sensitizes to GLI Inhibition
af: Anja S. Swoboda, et al.
Udgivet: (2023-10-01)

Using RUNX1 enhancer-reporter transgenic mouse models to dissect discrete stages of developmental hematopoiesis
af: Rode, C, et al.
Udgivet: (2014)

The dynamics of RUNX1-RUNX1T1 transcript levels after allogeneic hematopoietic stem cell transplantation predict relapse in patients with t(8;21) acute myeloid leukemia
af: Ya-Zhen Qin, et al.
Udgivet: (2017-02-01)

Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo
af: Zaniah N. Gonzalez Galofre, et al.
Udgivet: (2024-02-01)

Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of RUNX1-FPD
af: Martijn P. T. Ernst, et al.
Udgivet: (2023-02-01)

CBFβ initiates the hematopoietic stem cell program without obligatory binding to RUNX
af: Aldo Ciau-Uitz, et al.
Udgivet: (2017)

Locus-wide studies into the transcriptional regulation of Runx1 in developmental hematopoiesis
af: Jarratt, A
Udgivet: (2012)

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation
af: Abraham, Brian Joseph, et al.
Udgivet: (2022)

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation
Udgivet: (2021)

DISTINCT RUNX1 ENHANCERS DIRECT TRANSCRIPTION TO DISCRETE STAGES OF DEVELOPMENTAL HEMATOPOIESIS
af: O'Rourke, J, et al.
Udgivet: (2012)

A RUNX1-SMAD6 RHEOSTAT CONTROLS RUNX1 LEVELS AND REGULATES HEMATOPOIESIS IN THE DEVELOPING EMBRYO
af: Pimanda, J, et al.
Udgivet: (2010)

A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells.
af: van Riel, B, et al.
Udgivet: (2012)

RUNX1 regulates site specificity of DNA demethylation by recruitment of DNA demethylation machineries in hematopoietic cells
af: Takahiro Suzuki, et al.
Udgivet: (2017-09-01)

The truncated RUNX1/ETO activates VLA-4-dependent adhesion and migration of hematopoietic progenitor cells
af: Kanagaraju Ponnusamy, et al.
Udgivet: (2014-12-01)

RUNX1 loss renders hematopoietic and leukemic cells dependent on IL-3 and sensitive to JAK inhibition
af: Amy C. Fan, et al.
Udgivet: (2023-10-01)

Co-Expression of Runx1, Hoxa9, Hlf, and Hoxa7 Confers Multi-Lineage Potential on Hematopoietic Progenitors Derived From Pluripotent Stem Cells
af: Bo Yu, et al.
Udgivet: (2022-04-01)

RUNX3 levels in human hematopoietic progenitors are regulated by aging and dictate erythroid-myeloid balance
af: Peter Balogh, et al.
Udgivet: (2020-04-01)

Molecular profiling of acute myeloid leukemia with Runx1-Runx1t1 fusion
af: Magdy Elbordiny, et al.
Udgivet: (2024-12-01)

In rare acute myeloid leukemia patients harboring both RUNX1 and NPM1 mutations, RUNX1 mutations are unusual in structure and present in the germline
af: Jason H. Mendler, et al.
Udgivet: (2013-08-01)

RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia
af: Vasily V. Grinev, et al.
Udgivet: (2021-01-01)

Hematopoietic Transcription Factor RUNX1 is Essential for Promoting Macrophage–Myofibroblast Transition in Non‐Small‐Cell Lung Carcinoma
af: Philip Chiu‐Tsun Tang, et al.
Udgivet: (2024-01-01)

The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity.
af: Pimanda, J, et al.
Udgivet: (2007)

Prognosis of RUNX1-RUNX1T1 Rearrangement in Newly Diagnosed Acute Myeloid Leukemia Patients
af: Halima Babar, et al.
Udgivet: (2023-10-01)

Hemophagocytic Lymphohistiocytosis in RUNX1: : RUNX1T1 Positive AML with Blast Count Below 20%
af: Xingqin Huang, et al.
Udgivet: (2023-08-01)

Volunteer unrelated donor cell‐derived acute myeloid leukemia with RUNX1‐RUNX1T1
af: Shinya Hagiwara, et al.
Udgivet: (2021-05-01)

Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.
af: Landry, JR, et al.
Udgivet: (2008)

The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy
af: Claire C. Homan, et al.
Udgivet: (2021-07-01)

Ihh and Runx2/Runx3 signaling interact to coordinate early chondrogenesis: a mouse model.
af: Eun-Jung Kim, et al.
Udgivet: (2013-01-01)

Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukaemia
af: Robyn Lints, et al.
Udgivet: (2024-09-01)