The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters.
The transcription factor Runx1 plays a pivotal role in hematopoietic stem cell (HSC) emergence, and studies into its transcriptional regulation should give insight into the critical steps of HSC specification. Recently, we identified the Runx1 +23 enhancer that targets reporter gene expression to th...
Үндсэн зохиолчид: | Bee, T, Ashley, E, Bickley, SR, Jarratt, A, Li, P, Sloane-Stanley, J, Göttgens, B, de Bruijn, M |
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Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
2009
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Ижил төстэй зүйлс
Ижил төстэй зүйлс
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Alternative Runx1 promoter usage in mouse developmental hematopoiesis.
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Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.
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