Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya

Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya

Observed SARS-CoV-2 infections and deaths are low in tropical Africa raising questions about the extent of transmission. We measured SARS-CoV-2 IgG by ELISA in 9,922 blood donors across Kenya and adjusted for sampling bias and test performance. By 1st September 2020, 577 COVID-19 deaths were observe...

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Bibliographic Details
Main Authors: Adetifa, IMO, Uyoga, S, Gitonga, JN, Mugo, D, Otiende, M, Nyagwange, J, Karanja, HK, Tuju, J, Wanjiku, P, Aman, R, Mwangangi, M, Amoth, P, Kasera, K, Ng'ang'a, W, Rombo, C, Yegon, C, Kithi, K, Odhiambo, E, Rotich, T, Orgut, I, Kihara, S, Bottomley, C, Kagucia, EW, Gallagher, KE, Etyang, A, Voller, S, Lambe, T, Wright, D, Barasa, E, Tsofa, B, Bejon, P, Ochola-Oyier, LI, Agweyu, A, Scott, JAG, Warimwe, GM
Format: Journal article
Language:English
Published: Springer Nature 2021
Description
Summary:Observed SARS-CoV-2 infections and deaths are low in tropical Africa raising questions about the extent of transmission. We measured SARS-CoV-2 IgG by ELISA in 9,922 blood donors across Kenya and adjusted for sampling bias and test performance. By 1st September 2020, 577 COVID-19 deaths were observed nationwide and seroprevalence was 9.1% (95%CI 7.6-10.8%). Seroprevalence in Nairobi was 22.7% (18.0-27.7%). Although most people remained susceptible, SARS-CoV-2 had spread widely in Kenya with apparently low associated mortality.

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