New insights into the regulation of glucagon secretion by glucagon-like peptide-1.
Glucagon-like peptide-1 (GLP-1) is a potent incretin hormone currently under investigation for use as a novel therapeutic agent in the treatment of type 2 diabetes. One of several therapeutically important biological actions of GLP-1 in type 2 diabetic subjects is ability to induce strong suppressio...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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| _version_ | 1797075050294149120 |
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| author | Gromada, J Rorsman, P |
| author_facet | Gromada, J Rorsman, P |
| author_sort | Gromada, J |
| collection | OXFORD |
| description | Glucagon-like peptide-1 (GLP-1) is a potent incretin hormone currently under investigation for use as a novel therapeutic agent in the treatment of type 2 diabetes. One of several therapeutically important biological actions of GLP-1 in type 2 diabetic subjects is ability to induce strong suppression of glucagon secretion. The glucagonostatic action of GLP-1 results from its interaction with a specific G-protein coupled receptor resulting in the activation of adenylate cyclase and an increase in cAMP generation. In the pancreatic alpha-cell, cAMP, via activation of protein kinase A, interacts with a plethora of signal transduction processes including ion-channel activity and exocytosis of the glucagon-containing granules. In this short review, we will focus on recent advances in our understanding on the cellular mechanisms proposed to underlie the glucagonotropic action of GLP-1 and attempt to incorporate this knowledge into a working model for the control of glucagon secretion. Studies on the effects of GLP-1 on glucagon secretion are relevant to the pathogenesis of type 2 diabetes due to the likely contribution of hyperglucagonemia to impaired glucose tolerance in type 2 diabetes. |
| first_indexed | 2024-03-06T23:44:56Z |
| format | Journal article |
| id | oxford-uuid:7091aa40-195b-4b65-8e66-1f7bc09d1e0f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:44:56Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:7091aa40-195b-4b65-8e66-1f7bc09d1e0f2022-03-26T19:38:03ZNew insights into the regulation of glucagon secretion by glucagon-like peptide-1.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7091aa40-195b-4b65-8e66-1f7bc09d1e0fEnglishSymplectic Elements at Oxford2004Gromada, JRorsman, PGlucagon-like peptide-1 (GLP-1) is a potent incretin hormone currently under investigation for use as a novel therapeutic agent in the treatment of type 2 diabetes. One of several therapeutically important biological actions of GLP-1 in type 2 diabetic subjects is ability to induce strong suppression of glucagon secretion. The glucagonostatic action of GLP-1 results from its interaction with a specific G-protein coupled receptor resulting in the activation of adenylate cyclase and an increase in cAMP generation. In the pancreatic alpha-cell, cAMP, via activation of protein kinase A, interacts with a plethora of signal transduction processes including ion-channel activity and exocytosis of the glucagon-containing granules. In this short review, we will focus on recent advances in our understanding on the cellular mechanisms proposed to underlie the glucagonotropic action of GLP-1 and attempt to incorporate this knowledge into a working model for the control of glucagon secretion. Studies on the effects of GLP-1 on glucagon secretion are relevant to the pathogenesis of type 2 diabetes due to the likely contribution of hyperglucagonemia to impaired glucose tolerance in type 2 diabetes. |
| spellingShingle | Gromada, J Rorsman, P New insights into the regulation of glucagon secretion by glucagon-like peptide-1. |
| title | New insights into the regulation of glucagon secretion by glucagon-like peptide-1. |
| title_full | New insights into the regulation of glucagon secretion by glucagon-like peptide-1. |
| title_fullStr | New insights into the regulation of glucagon secretion by glucagon-like peptide-1. |
| title_full_unstemmed | New insights into the regulation of glucagon secretion by glucagon-like peptide-1. |
| title_short | New insights into the regulation of glucagon secretion by glucagon-like peptide-1. |
| title_sort | new insights into the regulation of glucagon secretion by glucagon like peptide 1 |
| work_keys_str_mv | AT gromadaj newinsightsintotheregulationofglucagonsecretionbyglucagonlikepeptide1 AT rorsmanp newinsightsintotheregulationofglucagonsecretionbyglucagonlikepeptide1 |