The association between unexpected weight loss and cancer diagnosis in primary care: a matched cohort analysis of 65,000 presentations
BACKGROUND:We aimed to understand the time period of cancer diagnosis and the cancer types detected in primary care patients with unexpected weight loss (UWL) to inform cancer guidelines. <br><br> METHODS:This retrospective matched cohort study used cancer registry linked electronic hea...
| Những tác giả chính: | , , , , , |
|---|---|
| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
Springer Nature
2020
|
| _version_ | 1826278520242831360 |
|---|---|
| author | Nicholson, BD Hamilton, W Koshiaris, C Oke, JL Hobbs, FDR Aveyard, P |
| author_facet | Nicholson, BD Hamilton, W Koshiaris, C Oke, JL Hobbs, FDR Aveyard, P |
| author_sort | Nicholson, BD |
| collection | OXFORD |
| description | BACKGROUND:We aimed to understand the time period of cancer diagnosis and the cancer types detected in primary care patients with unexpected weight loss (UWL) to inform cancer guidelines.
<br><br>
METHODS:This retrospective matched cohort study used cancer registry linked electronic health records from the UK's Clinical Practice Research Datalink from between 2000 and 2014. Univariable and multivariable time-to-event analyses examined the association between UWL, and all cancers combined, cancer site and stage.
<br><br>
RESULTS:In all, 63,973 patients had UWL recorded, of whom 1375 (2.2%) were diagnosed with cancer within 2 years (days-to-diagnosis: mean 181; median 80). Men with UWL (HR 3.28 (2.88-3.73)) and women (1.87 (1.68-2.08)) were more likely than comparators to be diagnosed with cancer within 3 months. The association was greatest in men aged ≥50 years and women ≥70 years. The commonest cancers were pancreas, cancer of unknown primary, gastro-oesophageal, lymphoma, hepatobiliary, lung, bowel and renal-tract. The majority were late-stage, but there was some evidence of association with stage II and stage III cancers. In the 3-24 months after presenting with UWL, cancer diagnosis was less likely than in comparators.
<br><br>
CONCLUSION:UWL recorded in primary care is associated with a broad range of cancer sites of early and late-stage. |
| first_indexed | 2024-03-06T23:45:08Z |
| format | Journal article |
| id | oxford-uuid:70a33a23-2d0f-49b5-9a21-c2bc504d409b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:45:08Z |
| publishDate | 2020 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:70a33a23-2d0f-49b5-9a21-c2bc504d409b2022-03-26T19:38:30ZThe association between unexpected weight loss and cancer diagnosis in primary care: a matched cohort analysis of 65,000 presentationsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:70a33a23-2d0f-49b5-9a21-c2bc504d409bEnglishSymplectic ElementsSpringer Nature2020Nicholson, BDHamilton, WKoshiaris, COke, JLHobbs, FDRAveyard, PBACKGROUND:We aimed to understand the time period of cancer diagnosis and the cancer types detected in primary care patients with unexpected weight loss (UWL) to inform cancer guidelines. <br><br> METHODS:This retrospective matched cohort study used cancer registry linked electronic health records from the UK's Clinical Practice Research Datalink from between 2000 and 2014. Univariable and multivariable time-to-event analyses examined the association between UWL, and all cancers combined, cancer site and stage. <br><br> RESULTS:In all, 63,973 patients had UWL recorded, of whom 1375 (2.2%) were diagnosed with cancer within 2 years (days-to-diagnosis: mean 181; median 80). Men with UWL (HR 3.28 (2.88-3.73)) and women (1.87 (1.68-2.08)) were more likely than comparators to be diagnosed with cancer within 3 months. The association was greatest in men aged ≥50 years and women ≥70 years. The commonest cancers were pancreas, cancer of unknown primary, gastro-oesophageal, lymphoma, hepatobiliary, lung, bowel and renal-tract. The majority were late-stage, but there was some evidence of association with stage II and stage III cancers. In the 3-24 months after presenting with UWL, cancer diagnosis was less likely than in comparators. <br><br> CONCLUSION:UWL recorded in primary care is associated with a broad range of cancer sites of early and late-stage. |
| spellingShingle | Nicholson, BD Hamilton, W Koshiaris, C Oke, JL Hobbs, FDR Aveyard, P The association between unexpected weight loss and cancer diagnosis in primary care: a matched cohort analysis of 65,000 presentations |
| title | The association between unexpected weight loss and cancer diagnosis in primary care: a matched cohort analysis of 65,000 presentations |
| title_full | The association between unexpected weight loss and cancer diagnosis in primary care: a matched cohort analysis of 65,000 presentations |
| title_fullStr | The association between unexpected weight loss and cancer diagnosis in primary care: a matched cohort analysis of 65,000 presentations |
| title_full_unstemmed | The association between unexpected weight loss and cancer diagnosis in primary care: a matched cohort analysis of 65,000 presentations |
| title_short | The association between unexpected weight loss and cancer diagnosis in primary care: a matched cohort analysis of 65,000 presentations |
| title_sort | association between unexpected weight loss and cancer diagnosis in primary care a matched cohort analysis of 65 000 presentations |
| work_keys_str_mv | AT nicholsonbd theassociationbetweenunexpectedweightlossandcancerdiagnosisinprimarycareamatchedcohortanalysisof65000presentations AT hamiltonw theassociationbetweenunexpectedweightlossandcancerdiagnosisinprimarycareamatchedcohortanalysisof65000presentations AT koshiarisc theassociationbetweenunexpectedweightlossandcancerdiagnosisinprimarycareamatchedcohortanalysisof65000presentations AT okejl theassociationbetweenunexpectedweightlossandcancerdiagnosisinprimarycareamatchedcohortanalysisof65000presentations AT hobbsfdr theassociationbetweenunexpectedweightlossandcancerdiagnosisinprimarycareamatchedcohortanalysisof65000presentations AT aveyardp theassociationbetweenunexpectedweightlossandcancerdiagnosisinprimarycareamatchedcohortanalysisof65000presentations AT nicholsonbd associationbetweenunexpectedweightlossandcancerdiagnosisinprimarycareamatchedcohortanalysisof65000presentations AT hamiltonw associationbetweenunexpectedweightlossandcancerdiagnosisinprimarycareamatchedcohortanalysisof65000presentations AT koshiarisc associationbetweenunexpectedweightlossandcancerdiagnosisinprimarycareamatchedcohortanalysisof65000presentations AT okejl associationbetweenunexpectedweightlossandcancerdiagnosisinprimarycareamatchedcohortanalysisof65000presentations AT hobbsfdr associationbetweenunexpectedweightlossandcancerdiagnosisinprimarycareamatchedcohortanalysisof65000presentations AT aveyardp associationbetweenunexpectedweightlossandcancerdiagnosisinprimarycareamatchedcohortanalysisof65000presentations |