Bacterial defences: mechanisms, evolution and antimicrobial resistance
<p>Throughout their evolutionary history, bacteria have faced diverse threats from other microorganisms, including competing bacteria, bacteriophages and predators. In response to these threats, they have evolved sophisticated defence mechanisms that today also protect bacteria against antibio...
| Váldodahkkit: | , , , |
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| Materiálatiipa: | Journal article |
| Giella: | English |
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Springer Nature
2023
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| Fáttát: |
| _version_ | 1826311221766258688 |
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| author | Smith, WPJ Wucher, BR Nadell, CD Foster, KR |
| author_facet | Smith, WPJ Wucher, BR Nadell, CD Foster, KR |
| author_sort | Smith, WPJ |
| collection | OXFORD |
| description | <p>Throughout their evolutionary history, bacteria have faced diverse threats from other microorganisms, including competing bacteria, bacteriophages and predators. In response to these threats, they have evolved sophisticated defence mechanisms that today also protect bacteria against antibiotics and other therapies. In this Review, we explore the protective strategies of bacteria, including the mechanisms, evolution and clinical implications of these ancient defences. We also review the countermeasures that attackers have evolved to overcome bacterial defences. We argue that understanding how bacteria defend themselves in nature is important for the development of new therapies and for minimizing resistance evolution.</p> |
| first_indexed | 2024-03-07T08:05:08Z |
| format | Journal article |
| id | oxford-uuid:70ab233c-f7e3-43b5-aed1-305a22e7f56b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:05:08Z |
| publishDate | 2023 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:70ab233c-f7e3-43b5-aed1-305a22e7f56b2023-10-24T09:51:10ZBacterial defences: mechanisms, evolution and antimicrobial resistanceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:70ab233c-f7e3-43b5-aed1-305a22e7f56bBacteriophagesBacterial toxinsClinical microbiologyAntimicrobial resistanceBacterial evolutionEnglishSymplectic ElementsSpringer Nature2023Smith, WPJWucher, BRNadell, CDFoster, KR<p>Throughout their evolutionary history, bacteria have faced diverse threats from other microorganisms, including competing bacteria, bacteriophages and predators. In response to these threats, they have evolved sophisticated defence mechanisms that today also protect bacteria against antibiotics and other therapies. In this Review, we explore the protective strategies of bacteria, including the mechanisms, evolution and clinical implications of these ancient defences. We also review the countermeasures that attackers have evolved to overcome bacterial defences. We argue that understanding how bacteria defend themselves in nature is important for the development of new therapies and for minimizing resistance evolution.</p> |
| spellingShingle | Bacteriophages Bacterial toxins Clinical microbiology Antimicrobial resistance Bacterial evolution Smith, WPJ Wucher, BR Nadell, CD Foster, KR Bacterial defences: mechanisms, evolution and antimicrobial resistance |
| title | Bacterial defences: mechanisms, evolution and antimicrobial resistance |
| title_full | Bacterial defences: mechanisms, evolution and antimicrobial resistance |
| title_fullStr | Bacterial defences: mechanisms, evolution and antimicrobial resistance |
| title_full_unstemmed | Bacterial defences: mechanisms, evolution and antimicrobial resistance |
| title_short | Bacterial defences: mechanisms, evolution and antimicrobial resistance |
| title_sort | bacterial defences mechanisms evolution and antimicrobial resistance |
| topic | Bacteriophages Bacterial toxins Clinical microbiology Antimicrobial resistance Bacterial evolution |
| work_keys_str_mv | AT smithwpj bacterialdefencesmechanismsevolutionandantimicrobialresistance AT wucherbr bacterialdefencesmechanismsevolutionandantimicrobialresistance AT nadellcd bacterialdefencesmechanismsevolutionandantimicrobialresistance AT fosterkr bacterialdefencesmechanismsevolutionandantimicrobialresistance |