DNA adducts and lung cancer risk: a prospective study
<p style="text-align:justify;"> Objectives were to investigate prospectively the ability of DNA adducts to predict cancer and to study the determinants of adducts, especially air pollutants. DNA adducts were measured in a case-control study nested in the European Prospective Investi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
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American Association for Cancer Research
2005
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| _version_ | 1826278551513464832 |
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| author | Peluso, M Munnia, A Hoek, G Krzyzanowski, M Veglia, F Airoldi, L Autrup, H Dunning, A Garte, S Hainaut, P Malaveille, C Gormally, E Matullo, G Overvad, K Raaschou-Nielsen, O Clavel-Chapelon, F Linseisen, J Boeing, H Trichopoulou, A Trichopoulos, D Kaladidi, A Palli, D Krogh, V Tumino, R Panico, S Bueno-De-Mesquita, HB Peeters, PH Kumle, M Gonzalez, CA Martinez, C Dorronsoro, M Barricarte, A Navarro, C Quiros, JR Berglund, G Janzon, L Jarvholm, B Day, NE Key, TJ Saracci, R Kaaks, R Riboli, E Vineis, P |
| author_facet | Peluso, M Munnia, A Hoek, G Krzyzanowski, M Veglia, F Airoldi, L Autrup, H Dunning, A Garte, S Hainaut, P Malaveille, C Gormally, E Matullo, G Overvad, K Raaschou-Nielsen, O Clavel-Chapelon, F Linseisen, J Boeing, H Trichopoulou, A Trichopoulos, D Kaladidi, A Palli, D Krogh, V Tumino, R Panico, S Bueno-De-Mesquita, HB Peeters, PH Kumle, M Gonzalez, CA Martinez, C Dorronsoro, M Barricarte, A Navarro, C Quiros, JR Berglund, G Janzon, L Jarvholm, B Day, NE Key, TJ Saracci, R Kaaks, R Riboli, E Vineis, P |
| author_sort | Peluso, M |
| collection | OXFORD |
| description | <p style="text-align:justify;"> Objectives were to investigate prospectively the ability of DNA adducts to predict cancer and to study the determinants of adducts, especially air pollutants. DNA adducts were measured in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) investigation. Cases included newly diagnosed lung cancer (n = 115), upper respiratory cancers (pharynx and larynx; n = 82), bladder cancer (n = 124), leukemia (n = 166), and chronic obstructive pulmonary disease or emphysema deaths (n = 77) accrued after a median follow-up of 7 years among the EPIC former smokers and never-smokers. Three controls per case were matched for questionnaire analyses and two controls per case for laboratory analyses. Matching criteria were gender, age, smoking status, country of recruitment, and follow-up time. Individual exposure to air pollution was assessed using concentration data from monitoring stations in routine air quality monitoring networks. Leukocyte DNA adducts were analyzed blindly using <sup>32</sup>P postlabeling technique. Adducts were associated with the subsequent risk of lung cancer, with an odds ratio (OR) of 1.86 [95% confidence interval (95% CI), 0.88-3.93] when comparing detectable versus nondetectable adducts. The association with lung cancer was stronger in never-smokers (OR, 4.04; 95% CI, 1.06-15.42) and among the younger age groups. After exclusion of the cancers occurring in the first 36 months of follow-up, the OR was 4.16 (95% CI, 1.24-13.88). A positive association was found between DNA adducts and ozone (O<sub>3</sub>) concentration. Our prospective study suggests that leukocyte DNA adducts may predict lung cancer risk of never-smokers. Besides, the association of DNA adduct levels with O<sub>3</sub> indicates a possible role for photochemical smog in determining DNA damage. </p> |
| first_indexed | 2024-03-06T23:45:36Z |
| format | Journal article |
| id | oxford-uuid:70c864ff-411a-44b4-97ac-32c6ae42aa6f |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:45:36Z |
| publishDate | 2005 |
| publisher | American Association for Cancer Research |
| record_format | dspace |
| spelling | oxford-uuid:70c864ff-411a-44b4-97ac-32c6ae42aa6f2022-03-26T19:39:36ZDNA adducts and lung cancer risk: a prospective studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:70c864ff-411a-44b4-97ac-32c6ae42aa6fSymplectic Elements at OxfordAmerican Association for Cancer Research2005Peluso, MMunnia, AHoek, GKrzyzanowski, MVeglia, FAiroldi, LAutrup, HDunning, AGarte, SHainaut, PMalaveille, CGormally, EMatullo, GOvervad, KRaaschou-Nielsen, OClavel-Chapelon, FLinseisen, JBoeing, HTrichopoulou, ATrichopoulos, DKaladidi, APalli, DKrogh, VTumino, RPanico, SBueno-De-Mesquita, HBPeeters, PHKumle, MGonzalez, CAMartinez, CDorronsoro, MBarricarte, ANavarro, CQuiros, JRBerglund, GJanzon, LJarvholm, BDay, NEKey, TJSaracci, RKaaks, RRiboli, EVineis, P <p style="text-align:justify;"> Objectives were to investigate prospectively the ability of DNA adducts to predict cancer and to study the determinants of adducts, especially air pollutants. DNA adducts were measured in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) investigation. Cases included newly diagnosed lung cancer (n = 115), upper respiratory cancers (pharynx and larynx; n = 82), bladder cancer (n = 124), leukemia (n = 166), and chronic obstructive pulmonary disease or emphysema deaths (n = 77) accrued after a median follow-up of 7 years among the EPIC former smokers and never-smokers. Three controls per case were matched for questionnaire analyses and two controls per case for laboratory analyses. Matching criteria were gender, age, smoking status, country of recruitment, and follow-up time. Individual exposure to air pollution was assessed using concentration data from monitoring stations in routine air quality monitoring networks. Leukocyte DNA adducts were analyzed blindly using <sup>32</sup>P postlabeling technique. Adducts were associated with the subsequent risk of lung cancer, with an odds ratio (OR) of 1.86 [95% confidence interval (95% CI), 0.88-3.93] when comparing detectable versus nondetectable adducts. The association with lung cancer was stronger in never-smokers (OR, 4.04; 95% CI, 1.06-15.42) and among the younger age groups. After exclusion of the cancers occurring in the first 36 months of follow-up, the OR was 4.16 (95% CI, 1.24-13.88). A positive association was found between DNA adducts and ozone (O<sub>3</sub>) concentration. Our prospective study suggests that leukocyte DNA adducts may predict lung cancer risk of never-smokers. Besides, the association of DNA adduct levels with O<sub>3</sub> indicates a possible role for photochemical smog in determining DNA damage. </p> |
| spellingShingle | Peluso, M Munnia, A Hoek, G Krzyzanowski, M Veglia, F Airoldi, L Autrup, H Dunning, A Garte, S Hainaut, P Malaveille, C Gormally, E Matullo, G Overvad, K Raaschou-Nielsen, O Clavel-Chapelon, F Linseisen, J Boeing, H Trichopoulou, A Trichopoulos, D Kaladidi, A Palli, D Krogh, V Tumino, R Panico, S Bueno-De-Mesquita, HB Peeters, PH Kumle, M Gonzalez, CA Martinez, C Dorronsoro, M Barricarte, A Navarro, C Quiros, JR Berglund, G Janzon, L Jarvholm, B Day, NE Key, TJ Saracci, R Kaaks, R Riboli, E Vineis, P DNA adducts and lung cancer risk: a prospective study |
| title | DNA adducts and lung cancer risk: a prospective study |
| title_full | DNA adducts and lung cancer risk: a prospective study |
| title_fullStr | DNA adducts and lung cancer risk: a prospective study |
| title_full_unstemmed | DNA adducts and lung cancer risk: a prospective study |
| title_short | DNA adducts and lung cancer risk: a prospective study |
| title_sort | dna adducts and lung cancer risk a prospective study |
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