APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'.

APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'.

Analysis of APC mutations in colonic and duodenal tumours from familial adenomatous polyposis (FAP) patients has shown that the site of the first hit, the germline mutation, can predict the type and position of the somatic mutation or 'second hit'. The two APC mutations are selected on the...

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Hlavní autoři: Latchford, A, Volikos, E, Johnson, V, Rogers, P, Suraweera, N, Tomlinson, I, Phillips, R, Silver, A
Médium: Journal article
Jazyk:English
Vydáno: 2007

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