Vascular density analysis in colorectal cancer patients treated with vatalanib (PTK787/ZK222584) in the randomised CONFIRM trials.
BACKGROUND: Pharmacological inhibitors of vascular endothelial growth factor (VEGF) receptors, like vatalanib, have been tested in randomised trials (CONFIRM (Colorectal Oral Novel therapy For the Inhibition of Angiogenesis and Retarding of Metastases) 1 and 2) in colorectal cancer showing activity...
Main Authors: | Giatromanolaki, A, Koukourakis, M, Sivridis, E, Gatter, K, Trarbach, T, Folprecht, G, Shi, M, Lebwohl, D, Jalava, T, Laurent, D, Meinhardt, G, Harris, A |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2012
|
Similar Items
-
Prognostic and predictive role of lactate dehydrogenase 5 expression in colorectal cancer patients treated with PTK787/ZK 222584 (vatalanib) antiangiogenic therapy.
by: Koukourakis, M, et al.
Published: (2011) -
A Phase I, open-label study with escalating doses of intravenous PTK787/ZK 222584, a multi-VEGF receptor inhibitor, followed by multiple oral daily dosing to assess the absolute bioavailability of PTK787/ZK 222584 after single and multiple doses in advanced cancer patients
by: Pavel, M, et al.
Published: (2005) -
Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma.
by: Hecht, JR, et al.
Published: (2011) -
Phase 1 Study of Combination Treatment with PTK 787/ZK 222584 and Cetuximab for Patients with Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics Analysis
by: Marlies H.G. Langenberg, et al.
Published: (2010-02-01) -
A phase II study of PTK787 in metastatic melanoma patients
by: Corrie, P, et al.
Published: (2008)