Maternal - offspring HLA-DRB1 compatibility in multiple sclerosis.
Major histocompatibility complex (MHC) compatibility has been reported to facilitate the long-term tolerance of fetal or maternally derived stem cells exchanged during pregnancy. Furthermore, such compatibility has been suggested to play a role in fetal viability. An increase in maternal - fetal hum...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2005
|
| _version_ | 1797075116676349952 |
|---|---|
| author | Willer, C Dyment, D Sadovnick, A Ebers, G |
| author_facet | Willer, C Dyment, D Sadovnick, A Ebers, G |
| author_sort | Willer, C |
| collection | OXFORD |
| description | Major histocompatibility complex (MHC) compatibility has been reported to facilitate the long-term tolerance of fetal or maternally derived stem cells exchanged during pregnancy. Furthermore, such compatibility has been suggested to play a role in fetal viability. An increase in maternal - fetal human leukocyte antigen (HLA) compatibility for class II DR alleles has previously been observed in the autoimmune disease scleroderma. Here, we examined the hypothesis that increased maternal - fetal MHC class II DR compatibility was associated with multiple sclerosis (MS) risk. HLA-DRB1 typing was performed in 2170 affected individuals and 2894 unaffected relatives from 1006 families with MS in at least two members. We found no evidence for increased HLA compatibility between affected individuals and their mothers, compared with unaffected individuals and their mothers, nor compared with affected individuals and their fathers. We also observed no excess of homozygosity of mothers compared with fathers of individuals with MS. In families in which the father shared exactly one allele with the mother, we found no excess in transmission of this allele to affected or unaffected offspring. These findings do not support a role for an excess maternal - fetal HLA-DRB1 compatibility in MS susceptibility. |
| first_indexed | 2024-03-06T23:45:46Z |
| format | Journal article |
| id | oxford-uuid:70d358c4-8cb7-491f-acb0-76f9f9ea35f7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:45:46Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:70d358c4-8cb7-491f-acb0-76f9f9ea35f72022-03-26T19:39:51ZMaternal - offspring HLA-DRB1 compatibility in multiple sclerosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:70d358c4-8cb7-491f-acb0-76f9f9ea35f7EnglishSymplectic Elements at Oxford2005Willer, CDyment, DSadovnick, AEbers, GMajor histocompatibility complex (MHC) compatibility has been reported to facilitate the long-term tolerance of fetal or maternally derived stem cells exchanged during pregnancy. Furthermore, such compatibility has been suggested to play a role in fetal viability. An increase in maternal - fetal human leukocyte antigen (HLA) compatibility for class II DR alleles has previously been observed in the autoimmune disease scleroderma. Here, we examined the hypothesis that increased maternal - fetal MHC class II DR compatibility was associated with multiple sclerosis (MS) risk. HLA-DRB1 typing was performed in 2170 affected individuals and 2894 unaffected relatives from 1006 families with MS in at least two members. We found no evidence for increased HLA compatibility between affected individuals and their mothers, compared with unaffected individuals and their mothers, nor compared with affected individuals and their fathers. We also observed no excess of homozygosity of mothers compared with fathers of individuals with MS. In families in which the father shared exactly one allele with the mother, we found no excess in transmission of this allele to affected or unaffected offspring. These findings do not support a role for an excess maternal - fetal HLA-DRB1 compatibility in MS susceptibility. |
| spellingShingle | Willer, C Dyment, D Sadovnick, A Ebers, G Maternal - offspring HLA-DRB1 compatibility in multiple sclerosis. |
| title | Maternal - offspring HLA-DRB1 compatibility in multiple sclerosis. |
| title_full | Maternal - offspring HLA-DRB1 compatibility in multiple sclerosis. |
| title_fullStr | Maternal - offspring HLA-DRB1 compatibility in multiple sclerosis. |
| title_full_unstemmed | Maternal - offspring HLA-DRB1 compatibility in multiple sclerosis. |
| title_short | Maternal - offspring HLA-DRB1 compatibility in multiple sclerosis. |
| title_sort | maternal offspring hla drb1 compatibility in multiple sclerosis |
| work_keys_str_mv | AT willerc maternaloffspringhladrb1compatibilityinmultiplesclerosis AT dymentd maternaloffspringhladrb1compatibilityinmultiplesclerosis AT sadovnicka maternaloffspringhladrb1compatibilityinmultiplesclerosis AT ebersg maternaloffspringhladrb1compatibilityinmultiplesclerosis |