Membrane-type matrix metalloproteinases: Their functions and regulations
Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further sub-classified into type I transmembrane-type (MT1, -MT2-, MT3- and MT5-MMPs) and glycosylphosphatidylinositol (GPI)-anchored type (M...
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| Format: | Journal article |
| Language: | English |
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Elsevier
2015
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| _version_ | 1797075117472219136 |
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| author | Itoh, Y |
| author_facet | Itoh, Y |
| author_sort | Itoh, Y |
| collection | OXFORD |
| description | Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further sub-classified into type I transmembrane-type (MT1, -MT2-, MT3- and MT5-MMPs) and glycosylphosphatidylinositol (GPI)-anchored type (MT4- and MT6-MMPs). In either case MT-MMPs are tethered to the plasma membrane, and this cell surface expression provides those enzymes with unique functionalities affecting various cellular behaviours. Among the 6 MT-MMPs, MT1-MMP is the most investigated enzyme and many of its roles and regulations have been revealed to date, but the potential roles and regulatory mechanisms of other MT-MMPs are gradually getting clearer as well. Further investigations of MT-MMPs are likely to reveal novel pathophysiological mechanisms and potential therapeutic strategies for different diseases in the future. |
| first_indexed | 2024-03-06T23:45:46Z |
| format | Journal article |
| id | oxford-uuid:70d4bc31-8050-4799-b304-3f726b71ee70 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:45:46Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:70d4bc31-8050-4799-b304-3f726b71ee702022-03-26T19:39:54ZMembrane-type matrix metalloproteinases: Their functions and regulationsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:70d4bc31-8050-4799-b304-3f726b71ee70EnglishSymplectic Elements at OxfordElsevier2015Itoh, YMembrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further sub-classified into type I transmembrane-type (MT1, -MT2-, MT3- and MT5-MMPs) and glycosylphosphatidylinositol (GPI)-anchored type (MT4- and MT6-MMPs). In either case MT-MMPs are tethered to the plasma membrane, and this cell surface expression provides those enzymes with unique functionalities affecting various cellular behaviours. Among the 6 MT-MMPs, MT1-MMP is the most investigated enzyme and many of its roles and regulations have been revealed to date, but the potential roles and regulatory mechanisms of other MT-MMPs are gradually getting clearer as well. Further investigations of MT-MMPs are likely to reveal novel pathophysiological mechanisms and potential therapeutic strategies for different diseases in the future. |
| spellingShingle | Itoh, Y Membrane-type matrix metalloproteinases: Their functions and regulations |
| title | Membrane-type matrix metalloproteinases: Their functions and regulations |
| title_full | Membrane-type matrix metalloproteinases: Their functions and regulations |
| title_fullStr | Membrane-type matrix metalloproteinases: Their functions and regulations |
| title_full_unstemmed | Membrane-type matrix metalloproteinases: Their functions and regulations |
| title_short | Membrane-type matrix metalloproteinases: Their functions and regulations |
| title_sort | membrane type matrix metalloproteinases their functions and regulations |
| work_keys_str_mv | AT itohy membranetypematrixmetalloproteinasestheirfunctionsandregulations |