Association study of MICA and MICB in Alzheimer's disease.
Following the replication of the association of the human leucocyte antigen (HLA) allele, HLA-B*07, with Alzheimer's disease (AD) in the cohort of the Oxford Project to Investigate Memory and Ageing (OPTIMA) in a previous study, we examined whether that association could be due to linkage diseq...
| Главные авторы: | , , , , , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
2009
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| _version_ | 1826278571973279744 |
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| author | Quiroga, I Lehmann, D Barnardo, M Fuggle, S Cortina-Borja, M Warden, DR Smith, A |
| author_facet | Quiroga, I Lehmann, D Barnardo, M Fuggle, S Cortina-Borja, M Warden, DR Smith, A |
| author_sort | Quiroga, I |
| collection | OXFORD |
| description | Following the replication of the association of the human leucocyte antigen (HLA) allele, HLA-B*07, with Alzheimer's disease (AD) in the cohort of the Oxford Project to Investigate Memory and Ageing (OPTIMA) in a previous study, we examined whether that association could be due to linkage disequilibrium with MICA or MICB alleles. We found a possible association of MICA*00801 heterozygotes with AD in subjects positive for the epsilon 4 allele of apolipoprotein E. This finding was supported by Hardy-Weinberg analysis, by stratified association analysis and by interaction analysis, but did not survive correction for multiple testing. In any case, these results do not explain our previously reported association of HLA-B*07 with AD. |
| first_indexed | 2024-03-06T23:45:55Z |
| format | Journal article |
| id | oxford-uuid:70e1f563-aa7e-4ff6-ad9e-ac45f1440b5d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:45:55Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:70e1f563-aa7e-4ff6-ad9e-ac45f1440b5d2022-03-26T19:40:12ZAssociation study of MICA and MICB in Alzheimer's disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:70e1f563-aa7e-4ff6-ad9e-ac45f1440b5dEnglishSymplectic Elements at Oxford2009Quiroga, ILehmann, DBarnardo, MFuggle, SCortina-Borja, MWarden, DRSmith, AFollowing the replication of the association of the human leucocyte antigen (HLA) allele, HLA-B*07, with Alzheimer's disease (AD) in the cohort of the Oxford Project to Investigate Memory and Ageing (OPTIMA) in a previous study, we examined whether that association could be due to linkage disequilibrium with MICA or MICB alleles. We found a possible association of MICA*00801 heterozygotes with AD in subjects positive for the epsilon 4 allele of apolipoprotein E. This finding was supported by Hardy-Weinberg analysis, by stratified association analysis and by interaction analysis, but did not survive correction for multiple testing. In any case, these results do not explain our previously reported association of HLA-B*07 with AD. |
| spellingShingle | Quiroga, I Lehmann, D Barnardo, M Fuggle, S Cortina-Borja, M Warden, DR Smith, A Association study of MICA and MICB in Alzheimer's disease. |
| title | Association study of MICA and MICB in Alzheimer's disease. |
| title_full | Association study of MICA and MICB in Alzheimer's disease. |
| title_fullStr | Association study of MICA and MICB in Alzheimer's disease. |
| title_full_unstemmed | Association study of MICA and MICB in Alzheimer's disease. |
| title_short | Association study of MICA and MICB in Alzheimer's disease. |
| title_sort | association study of mica and micb in alzheimer s disease |
| work_keys_str_mv | AT quirogai associationstudyofmicaandmicbinalzheimersdisease AT lehmannd associationstudyofmicaandmicbinalzheimersdisease AT barnardom associationstudyofmicaandmicbinalzheimersdisease AT fuggles associationstudyofmicaandmicbinalzheimersdisease AT cortinaborjam associationstudyofmicaandmicbinalzheimersdisease AT wardendr associationstudyofmicaandmicbinalzheimersdisease AT smitha associationstudyofmicaandmicbinalzheimersdisease |